Mutations in collagen and related proteins are the primary cause of EDS Facebook X (Twitter) WhatsApp LinkedIn Pinterest Copy link From genes to joints: how Ehlers-Danlos Syndrome is shaped by genetics 12/09/25, 12:12 Last updated: Published: 08/11/24, 11:40 Mutations in collagen and related proteins are the primary cause of EDS This is article no. 10 in a series on rare diseases. Next article: CEDS- a break in cell death . Previous article: Breaking down Tay-Sachs . Ehlers-Danlos Syndrome (EDS) is a group of 13 inherited disorders that affect connective tissues, particularly collagen. Collagen is a crucial protein in the body that provides structure and strength to skin, joints, and blood vessels. Mutations in collagen or collagen-modifying proteins are the primary cause of the types of EDS. EDS manifests through a range of symptoms that vary significantly depending on the specific type of EDS. However, there are common symptoms that many individuals with EDS experience, particularly related to joint and skin issues. For instance, joints can move beyond the normal range, leading to frequent dislocations and subluxations, also called joint hypermobility. Additionally, the skin can be stretched more than usual, which creates a soft and velvety appearance known as skin hyperextensibility. As mentioned in Figure 1 , skin bruising, scarring and tearing are common symptoms, leading to individuals often experiencing chronic pain. Life expectancy for individuals with EDS varies depending on the type of disorder an individual has. This is due to how specific forms can have structural changes in organs and tissues, which can lead to serious life-threatening complications. For example, vascular EDS (vEDS) is associated with a significantly reduced life expectancy due to the risk of spontaneous rupture of major blood vessels, intestines, and other hollow organs. Most other forms of EDS, such as classical EDS (cEDS), hypermobile EDS (hEDS), and kyphoscoliotic EDS (kEDS), generally do not significantly affect life expectancy. However, the health complications that patients have can substantially impact their quality of life. Genetic basis As stated, the various types of EDS encompass many genetic defects, for example, cEDS is linked to mutations in the COL5A1 or COL5A2 genes, which encode the α1 and α2 chains of type V collagen. Following an autosomal dominant inheritance pattern, 50% of cEDS diagnoses inherit the condition from an affected parent, while the other half from a new (de novo) pathogenic variant. Diagnosing EDS encompasses a variety of methods. Firstly, differential diagnosis may be used to distinguish between subtypes like cEDS and hEDS by evaluating clinical features such as the presence of joint hypermobility, skin characteristics, and scarring patterns. Clinicians use these specific symptoms along with family history to differentiate between the subtypes since some, like hEDS, lack identified genetic markers, making this clinical assessment essential for accurate diagnosis and management. This process helps exclude other conditions and accurately identify the EDS subtype. Also, suggestive clinical features identifying pathogenic or likely pathogenic variants in the COL5A1 or COL5A2 genes can be done through molecular genetic testing. This testing can be approached in two ways: targeted multigene panels, which focus on specific genes like COL5A1 and COL5A2 . Alternatively, comprehensive genomic testing, such as exome or genome sequencing, does not require preselecting specific genes and is useful when the clinical presentation overlaps with other inherited disorders. Mutations in COL5A1 and COL5A2 can include missense, nonsense, splice site variants, or small insertions and deletions, all of which impair the function of type V collagen. Missense mutations result in the substitution of one amino acid for another, disrupting the collagen triple helix structure and affecting its stability and function. On the other hand, nonsense mutations lead to a premature stop codon, producing a truncated and usually non-functional protein. Splice site mutations interfere with the normal splicing of pre-mRNA, resulting in aberrant proteins. These mutations in COL5A1 and COL5A2 lead to the characteristic features of cEDS, such as highly elastic skin and joint hypermobility. Furthermore, different types of EDS are caused by specific genetic mutations, each affecting collagen in distinct ways and necessitating varied treatment approaches. VEDS is caused by mutations in the COL3A1 gene, which affects type III collagen and leads to fragile blood vessels and a higher risk of organ rupture. kEDS results from mutations in the PLOD1 or FKBP14 genes, impacting collagen cross-linking, and presents with severe scoliosis and muscle hypotonia. Arthrochalasia EDS (aEDS), due to mutations in the COL1A1 or COL1A2 genes that affect type I collagen, features severe joint hypermobility and congenital hip dislocation. Dermatosparaxis EDS (dEDS) is caused by mutations in the ADAMTS2 gene, which is crucial for processing type I collagen, leading to extremely fragile skin and severe bruising. Each type of EDS highlights the critical role of specific genetic mutations in the structural integrity and function of collagen, which consequently influences treatment approaches. Treatment Treatments for EDS primarily focus on managing symptoms and preventing complications due to the underlying genetic defects affecting collagen. Pain relief through nonsteroidal anti-inflammatory drugs (NSAIDs), acetaminophen, and sometimes opioids is common, addressing chronic pain related to joint and muscle issues. Moreover, physical therapy may help strengthen muscles around hypermobile joints, reducing the risk of dislocations and improving stability. Orthopaedic interventions, such as braces and orthotics, are also used to support joint function, and surgery may be considered in severe cases. Cardiovascular care is crucial, especially for vEDS, involving regular monitoring with imaging techniques to detect arterial problems early. Preventive vascular surgery might be necessary to repair aneurysms or other vascular defects. Wound care includes using specialised dressings to handle fragile skin and prevent extensive scarring, relevant to mutations in genes like COL5A1 and COL5A2 in classical EDS. Understanding the specific genetic mutations helps tailor these treatments to address the particular collagen-related defects and associated complications in different EDS types. Moreover, clinical trials for treating EDS have shown both positive and negative results. For example, trials investigating the efficacy of physical therapy in strengthening muscles around hypermobile joints have shown positive outcomes in reducing joint instability and improving function. On the other hand, trials aiming to directly modify the underlying genetic defects in collagen production have faced significant challenges. Gene therapy approaches and other experimental treatments targeting specific mutations, such as those in COL5A1 or COL3A1 genes, have shown limited success and faced hurdles in achieving sufficient therapeutic benefit without adverse effects. This is evident as in mouse models the deletion of COL3A1 resulted in aortic and gastrointestinal rupture meaning that simply restoring one functional copy may not be sufficient to prevent the disease. Moreover, the unknown and partial success in identifying mutations responsible for all EDS cases has further bolstered the struggle for researchers to establish comprehensive treatment strategies. In vEDS, as it is a dominantly inherited disorder, adding a healthy copy of the gene (a common strategy in gene therapy) is ineffective because the defective gene still produces harmful proteins. Research has highlighted, however, that the combination of RNAi-mediated mutant allele-specific gene silencing and transcriptional activation of a normal allele could help as a promising strategy for vascular Ehlers-Danlos Syndrome. In the experiment, researchers used small interfering RNA (siRNA) to selectively reduce the mutant COL3A1 mRNA levels by up to 80%, while simultaneously using lysyl oxidase (LOX) to boost the expression of the normal COL3A1 gene. This dual approach successfully increased the levels of functional COL3A1 mRNA in patient cells, suggesting a potential therapeutic strategy for this condition. Conclusion In conclusion, EDS represents a diverse group of inherited connective tissue disorders, primarily caused by mutations in collagen or collagen-modifying proteins. These genetic defects result in a wide range of symptoms, including joint hypermobility, skin hyperextensibility, and vascular complications, which vary significantly across the 13 different types of EDS. Diagnosing and treating EDS is complex and largely dependent on the specific genetic mutations involved. While current treatments mainly focus on managing symptoms and preventing complications, advances in genetic research, such as RNAi-mediated gene silencing and transcriptional activation, show promise for more targeted therapies, especially for severe forms like vascular EDS. However, challenges remain in developing comprehensive and effective treatments, underscoring the need for ongoing research and personalised medical approaches to improve the quality of life for individuals with EDS. Written by Imron Shah Related articles: Hypermobility spectrum disorders / Therapy for skin disease REFERENCES Malfait, F., Wenstrup, R.J. and De Paepe, A. (2010). Clinical and genetic aspects of Ehlers-Danlos syndrome, classic type. Genetics in Medicine, 12(10), pp.597–605. doi: https://doi.org/10.1097/gim.0b013e3181eed412 . Miklovic, T. and Sieg, V.C. (2023). Ehlers Danlos Syndrome. [online] PubMed. Available at: https://www.ncbi.nlm.nih.gov/books/NBK549814/ . Sobey, G. (2014). Ehlers–Danlos syndrome – a commonly misunderstood group of conditions. Clinical Medicine, [online] 14(4), pp.432–436. doi: https://doi.org/10.7861/clinmedicine.14-4-432 . Watanabe, A., Wada, T., Tei, K., Hata, R., Fukushima, Y. and Shimada, T. (2005). 618. A Novel Gene Therapy Strategy for Vascular Ehlers-Danlos Syndrome by the Combination with RNAi Mediated Inhibition of a Mutant Allele and Transcriptional Activation of a Normal Allele. Molecular Therapy, [online] 11, p.S240. doi: https://doi.org/10.1016/j.ymthe.2005.07.158 . FURTHER READING The Ehlers-Danlos Society - A global organisation dedicated to supporting individuals with EDS and raising awareness about the condition by providing extensive information on the different types of EDS, updates on research, and resources for patients https://www.ehlers-danlos.com/ PubMed - For those interested in academic research, articles and studies on EDS. https://www.ncbi.nlm.nih.gov/pmc/?term=ehlers-danlos+syndrome Cleveland Clinic – A clinic with an extensive health library providing easy to understand and informative information about the syndrome. https://my.clevelandclinic.org/health/diseases/17813-ehlers-danlos-syndrome Project Gallery

Health in Syria and Lebanon are hindered by inequities and inequalities stemming primarily from warfare Facebook X (Twitter) WhatsApp LinkedIn Pinterest Copy link Syria and Lebanon’s diverging yet connected struggles Last updated: 03/05/26, 18:23 Published: 19/06/25, 08:00 Health in Syria and Lebanon are hindered by inequities and inequalities stemming primarily from warfare This is article no. 4 in a series about global health injustices. Previous article: Yemen- a neglected humanitarian crisis . Next article: Injustices in conflicted Kashmir . Introduction Welcome to the fourth article of the Global Health Injustices Series. The previous article discussed Yemen, specifically how the health and well-being of the population are affected by the intricate geopolitics at play. In this article, I collaborated with Jana Antar , to discuss Syria and Lebanon. Although these countries border one another, they encounter distinct challenges. Similar to previous articles, the health and wellbeing of the Syrian and Lebanese people are hindered by the inequities and inequalities stemming primarily from warfare. Impact of war on healthcare: Syria's deliberate destruction Since the onset of the Syrian conflict in 2011, the country’s healthcare system has been systematically dismantled. Beyond the direct casualties of war, the destruction of hospitals, clinics, and medical supply chains has led to a secondary crisis, one where preventable deaths become inevitable. Between 2011 and 2020, Physicians for Human Rights documented nearly 600 attacks on healthcare facilities. Since 2 March 2026, 92 attacks on health care have been reported in Lebanon, resulting in 137 injuries and 53 deaths. The deliberate targeting of hospitals and medical personnel has rendered healthcare not just a casualty of war, but a weapon of war itself ( Figure 1 ). This destruction has had catastrophic consequences. Maternal and infant mortality rates have soared, vaccination coverage has plummeted, and chronic disease management has become nearly impossible. In the northwest of Syria, where displaced populations reside in makeshift camps, infectious diseases such as cholera and tuberculosis continue to spread due to poor sanitation and lack of medical oversight. The COVID-19 pandemic only exacerbated these challenges, whereby 46% of reported cases in Northwest Syria resulted in death due to the collapse of medical infrastructure. As of early 2025, only 57% of hospitals and 37% of primary healthcare centres in Syria remain fully functional. The remaining facilities operate under severe constraints due to damage from attacks and resource shortages. In 2024 alone, there were 77 attacks on healthcare facilities, further disrupting access to trauma care, maternal health, and treatment for chronic illnesses. Overcrowding in displacement camps and poor sanitation have also heightened the risk of outbreaks such as tuberculosis, making urgent intervention critical ( Figure 2 ). Impact of war on healthcare: Lebanon's fragile healthcare system Lebanon, a country once regarded as a regional medical hub, has borne the brunt of Syria’s refugee crisis. With an estimated 1.5 million Syrian refugees seeking shelter within its borders, the country has faced a 50% surge in demand for healthcare services. The healthcare system, already strained before the crisis, has since crumbled under the weight of economic collapse, political instability, and donor fatigue. The Lebanese economic crisis, which began in 2019, had devastating effects on healthcare delivery. The Lebanese pound has lost over 90% of its value, placing essential medical supplies out of reach for hospitals and individuals. Pharmacies frequently run out of life-saving medications, power outages disrupt critical care units, and the departure of healthcare professionals has left hospitals understaffed. The situation has worsened due to escalating hostilities, starting from the south of Lebanon and later expanding, displacing over 112,000 people as of February 2025. The violence has led to the closure of 130 primary health centres and seven hospitals, with 15 out of 153 hospitals either non-functional or operating at reduced capacity. In Nabatieh Governorate alone, 40% of hospital bed capacity has been lost. Attacks on health workers and facilities continued to mount between January and November 2024, when 137 attacks were reported, nearly half of which resulted in fatalities. These disruptions create a ripple effect, limiting immediate medical care and undermining public health initiatives such as vaccination programs and maternal health services. NGOs: the last line of defence In the face of government inaction, non-governmental organisations (NGOs) have become the backbone of healthcare provision in Syria and Lebanon. International and local NGOs have mobilised to provide vaccination campaigns, mental health support, and medical supplies to those in need. For example, WHO and UNICEF have facilitated vaccination drives, reaching 250,000 children under five years old, 30% of whom were displaced Syrians. However, while NGOs have played a crucial role in mitigating healthcare crises, their efforts remain primarily reactive rather than systemic and preventative, addressing immediate needs without long-term sustainability, and not adequately focusing on precautionary measures to avoid these undesirable situations. In fact, NGOs face mounting challenges. The overwhelming demand for services, lack of sustainable funding, and security threats have made it increasingly difficult for organisations to operate. Moreover, while NGOs are stretched in their deliverables, the humanitarian workers encounter frequent targeting, making their mission even more perilous. Conclusion: the role of the international community The crises in Syria and Lebanon are not isolated events; they are a reflection of global health injustices that demand international attention and intervention. Providing short-term aid is no longer enough, so long-term solutions must be prioritised to rebuild these destroyed healthcare systems. Moreover, de-escalating both crises would improve health outcomes for the vulnerable communities in Syria and Lebanon. The next article will focus on the population in conflicted Kashmir; addressing their injustices is crucial because of the profound impact and lack of coverage in mainstream discussions. Written by Jana Antar and Sam Jarada Related articles: Understanding health through different stances / Ethnic , and Socioeconomic health equalities REFERENCES A Decade of Destruction: Attacks on health care in Syria. The IRC. 2025. Available from: https://www.rescue.org/report/decade-destruction-attacks-health-care-syria-0 The Syrian Conflict: Eight Years of Devastation and Destruction of the Health System - PHR. PHR. 202. Available from: https://phr.org/our-work/resources/the-syrian-conflict-eight-years-of-devastation-and-destruction-of-the-health-system/ Ammar W, Kdouh O, Hammoud R, Hamadeh R, Harb H, Ammar Z, et al. Health system resilience: Lebanon and the Syrian refugee crisis. Journal of Global Health. 2016 Dec;6(2). Available from: https://pmc.ncbi.nlm.nih.gov/articles/PMC5234495/ Lebanon 2025 Indicators and Targets Lebanon Multi-year Strategy 2023 -2025. Available from: https://reporting.unhcr.org/sites/default/files/2025-01/Lebanon%20-%20Strategy%202023%20%E2%80%93%202025_0.pdf Lebanon | Humanitarian Action. Humanitarianaction.info . 2024. Available from: https://humanitarianaction.info/document/global-humanitarian-overview-2025/article/lebanon-1 WHO. WHO’s Health Emergency Appeal 2025 [Internet]. 2025. Available from: https://cdn.who.int/media/docs/default-source/documents/emergencies/2025-appeals/2025-hea-lebanon.pdf?sfvrsn=45f2a018_5&download=true Lebanon’s Pharmaceutical Sector: Challenges, Opportunities, and Strategic Solutions. LCPS. 2025. Available from: https://www.lcps lebanon.org/en/articles/details/4903/lebanon%E2%80%99s-pharmaceutical-sector-challenges-opportunities-and-strategic-solutions Sousa C, Akesson B, Badawi D. “Most importantly, I hope God keeps illness away from us”: The context and challenges surrounding access to health care for Syrian refugees in Lebanon. Global Public Health. 2020 Jun 12;1–10. Syrian refugee access to healthcare in Lebanon - Lebanon. ReliefWeb. 2020. Available from: https://reliefweb.int/report/lebanon/syrian-refugee-access-healthcare-lebanon World. Lebanon: a conflict particularly destructive to health care [Internet]. Who.int . World Health Organization: WHO; 2024. Available from: https://www.who.int/news/item/22-11-2024-lebanon--a-conflict-particularly-destructive-to-health-care Project Gallery

Examining disconnection strategies and Functional Group Interconversion (FGI) Facebook X (Twitter) WhatsApp LinkedIn Pinterest Copy link Molecular blueprints: the art of synthetic planning Last updated: 05/03/26, 14:47 Published: 19/02/26, 08:00 Examining disconnection strategies and Functional Group Interconversion (FGI) This is article no. 1 in a two-part series on retrosynthesis. Next article: Synthesis of ibuprofen . Introduction Science is often seen as rigid, driven solely by facts and logic. Yet, in the world of chemical synthesis, molecular design and retrosynthetic analysis can be considered an art form. Synthetic creativity can be measured by the number of steps, environmental considerations, or the clever assembly of chemical building blocks. Widely used in the pharmaceutical industry and responsible for many Nobel Prize‑winning discoveries, retrosynthetic planning is central to modern synthetic chemistry. 1. Disconnection Strategy Retrosynthesis begins with deconstructing a target molecule into simpler starting materials known as synthons. A synthon is hypothetical but represents a fragment that could react to form a target molecule. Chemists then match synthons to real‑life equivalents (R.L.E.) which can be used in the lab. For example, if a target molecule contains an ester group, cleaving the oxygen–carbonyl bond produces four possible synthons ( Figure 1 ). Of these synthons, the positively charged oxygen has no R.L.E., so pairing the negatively charged oxygen with a carbonyl‑containing R.L.E., such as a carboxylic acid or acid chloride, and an alcohol will effectively synthesise the desired ester. 2. Functional Group Interconversion (FGI) FGIs are exploited by chemists when a functional group is difficult to manipulate directly. In these cases, the target functional group is converted to another functional group which is easier to work with. For instance, this strategy is commonly used to synthesise alkene and carboxylic acid fragments. As alkenes mainly participate in addition reactions, forming C–C bonds can prove difficult; therefore, converting the alkene to an alkyne can make this simpler. As an alkyne‑to‑alkene transformation is relatively simple, using either Lindlar’s catalyst (Z‑alkene) or Na/NH₃ (E‑alkene), alkynes can be used to build up the carbon chain before a final reduction. This is done by simple nucleophilic substitutions promoted by base deprotonation (NaNH₂) of the alkyne. The same idea is used for installing carboxylic acids, as a common FGI is to use a nitrile group (CN). These can be easily transformed back to the target carboxylic acid using acid in aqueous conditions. 3. Synthesis of Aspirin Retrosynthetic analysis can be used to design synthetic routes to common pharmaceuticals. For aspirin, a good disconnection strategy would be to break the ester bond and derive R.L.E. as shown above. To install the carboxylic acid, an FGI can be used. In Figure 3, two possible syntheses are highlighted utilising these strategies. While the synthetic methods presented previously will produce aspirin in high yields, they often create large amounts of waste and use harsh acidic conditions. Bhuyan et al. have proposed a more sustainable synthesis using blue LED light to catalyse the reaction under an O₂ atmosphere ( Figure 4) . Conclusion In conclusion, retrosynthesis and synthetic planning are essential tools for designing complex molecules. While the disconnection strategy and FGIs are relatively simple concepts, their application is used routinely in both industry and academia, regardless of the complexity of the target molecule. While one strategy may be used routinely, there are often many more ways to synthesise a particular compound more efficiently or with more flair. Stay tuned for Part 2, where the techniques discussed here are applied to the synthesis of ibuprofen. Written by Antony Lee Project Gallery

The novelty of quantum computing Facebook X (Twitter) WhatsApp LinkedIn Pinterest Copy link Understanding Quantum Computing and Its Applications 11/04/26, 14:50 Last updated: Published: 03/06/23, 18:18 The novelty of quantum computing Relative to the inception of modern technology, quantum computing is fairly young. In 1998, Isaac Chuang of the Los Alamos National Laboratory, Neil Gershenfeld of the Massachusetts Institute of Technology (MIT), and Mark Kubinec of the University of California at Berkeley created the first quantum computer that could be loaded with data and output a solution. This marked a significant breakthrough moment for the world of computing and technology. To understand quantum computing, we must first delve into the basics of a regular computer. At the core, a computer operates based on a binary system of 1s and 0s, akin to an on/off switch. However, quantum computers go beyond this simplicity. Quantum computers utilize quantum bits, or qubits, which can exist in a superposition of states, representing both 0 and 1 simultaneously. This property allows quantum computers to perform parallel computations and leverage quantum phenomena like entanglement and interference to solve certain problems more efficiently than classical computers. Superposition, the ability of qubits to exist in multiple states simultaneously, is one of the unique properties of quantum mechanics that enables quantum computers to perform computations differently than classical computers. It offers new possibilities for information processing and solving complex tasks. One notable recent project in the field of quantum computing involved Google's use of a 53-qubit quantum computer named Sycamore. This quantum computer successfully performed a computation that would have taken the most powerful classical supercomputers thousands of years to complete, accomplishing it in just a few minutes. This research project exemplified the immense potential of quantum computers for tackling complex problems in a remarkable manner. As we continue to unlock the mysteries of quantum computing and overcome technical challenges, we stand at the brink of a new era of innovation and discovery. From advancements in drug discovery and optimization to revolutionizing cryptography and financial modelling, the possibilities are immense. The progress made so far in quantum computing is incredibly promising (it will soon be ready for commercialisation), and it is an exciting field that holds the key to tackling some of the world's most pressing challenges. Written by Jaspreet Mann Related articles: Quantum chemistry / Computational organic chemistry REFERENCES Chuang, I., Gershenfeld, N., & Kubinec, M. (1998). Experimental implementation of fast quantum searching. Physical Review Letters, 80(15), 3408–3411. Nielsen, M. A., & Chuang, I. L. (2010). Quantum Computation and Quantum Information: 10th Anniversary Edition. Cambridge University Press. Arute, F., et al. (2019). Quantum supremacy using a programmable superconducting processor. Nature, 574(7779), 505–510. Daskin, A., et al. (2021). Quantum Computing: Progress and Prospects. National Academies Press. Project Gallery

Broadening access for (black) women in STEM Facebook X (Twitter) WhatsApp LinkedIn Pinterest Copy link Power of sisterhood in STEM Last updated: 28/03/25, 11:10 Published: 28/03/25, 08:00 Broadening access for (black) women in STEM In collaboration with SiSTEM for International Women's Month Entering a fluid dynamics lecture. Looking under a microscope confined to the four walls of a lab. Walking onto a construction site or a board meeting. As a woman in these spaces, particularly as a woman of colour it is easy to believe you are the ONLY one. That’s what we thought, two sisters of black heritage starting out in the biomedical and the engineering field respectively. The higher we went in education the less people that looked like us. Being 1 of 10 women in a cohort of 200 was a familiar sight. Being less than 2% of the engineering workforce as a woman, you can start to feel like science, technology, engineering and maths (STEM) is not for you. But the reality is there are women in STEM doing incredible work. STEM is not a man’s industry. As women, we deserve our space on the STEM table. Through our struggles and isolating experiences, we decided to create SiSTEM, a community for all these wonderful women. Real life sisterhood We are often asked how we find working with your sister. Truth is, we wouldn’t be each other’s first choice for a business partner! We never thought we would start an organisation together, growing up as most siblings we have always wanted to do our own thing. Science and engineering was always seen as us doing separate things. Moreover we have completely different personalities. But we are two sisters with one dream; we don’t want another girl to leave the STEM field because she doesn’t believe she belongs there. We don’t want another girl to disqualify herself from her STEM career or degree because she has been told she doesn’t have the look for STEM or grades to do well. We have one passion and that’s to change the narrative of women in STEM, particularly black women and those from lower socioeconomic backgrounds. There is power in numbers Community and having a support system are important. We wouldn’t have completed our STEM degrees or broken into our careers without our personal sisterly support. We were always a phone call away for each other, ready to be a listening ear and a cheerleader. That same sisterly support is what we offer to other women and girls through our initiative. There’s power in sisterhood, standing on the shoulders of great women. Women face unique challenges particularly in the STEM industry, discrimination, feeling less valued, difficulty with pay and promotion but by building a culture of support we empower women to thrive despite the barriers. It’s beautiful to belong to a circle of women as we are stronger together. By belonging to a community it cultivates a feeling of belonging. You also learn from one another, sparking interesting conversations, building important connections. We learn from our community everyday: the conversations we are able to have inspire us and broaden our knowledge. Throwing the rope to the next generation From its inception, SiSTEM’s goal was to support women and girls throughout their STEM journey. The gender gap issue in STEM starts very early on, very often not when we choose our degree courses but as early as primary school. That’s why we empower young girls as young as five years old. Every girl, every woman deserves to be part of a community. Every stage of the journey has its unique challenges which belonging to community can help navigate. I’m sure you’ve heard the saying ‘empowered women empower women’ - now we feel empowered to empower other girls and women. We originally felt like we were not the people to create this community. Imposter syndrome told us we weren’t qualified enough, that we didn’t have a story to tell worth listening to. Reflecting on our own journeys, it’s women like our teachers, our mother, our friends who have been key in our success. Our mum telling us to ‘aim high and be the best’, a female science teacher telling us ‘you can be whatever you want to be’, a friend's comment on our graduation post saying how proud they are. And now a community of women who we can lean on for support, receive advice and inspire us every day. Today, we meet women at schools, events, universities and workplaces. A common theme in some of these women and girls we meet is a lack of confidence. Our biggest joy is when we are able to put a smile on a young girl’s face who feels giving up.Women need reminding how amazing they are so we continue to do amazing things, find a cure for cancer, make an innovative product to solve the world’s biggest problems or to design a beautiful building which would will be seen by generations to come. We shouldn’t be afraid to share our personal stories of how we got to where we are. when others hear they are empowered. This is what we use our platform to do. We are able to pass on the mic to other woman to share their untold stories. By putting a light on various women particularly black women in STEM we are giving others positive roles models to look to where they able to believe they do can do it. An empowered woman is a force of nature. She shines. She encourages. She breaks barriers and has the confidence to speak up in a place where she was told to be silent. By forming our community even though we may still find that we are the only women in the room, we have many women standing behind us and many more coming. Conclusion Retention of women in STEM is as equally as important as getting women into STEM. There is a leaky pipeline particularly between university level and STEM leadership positions and also many young girls already have a negative perception about certain STEM careers. That’s why we created an initiative to encourage more girls to get into STEM through innovative workshops and outreach programs and to create a community for women currently in the field. By doing so we aim to open the bottle top at one end and close any holes at the other end. Women supporting women in a powerful thing and there is space for all women in stem, no matter your background, academic records or skin colour. Together we make STEM colourful…preferably pink! -- Scientia News wholeheartedly thanks SiSTEM for this important piece on female representation in STEM. We hope you enjoyed reading this International Women's Month Special piece! For more information, check them out on Instagram and LinkedIn . -- Related articles: Representation in STEM / Women leading in biomedical engineering / African-American women in cancer research Project Gallery

IT cells and their impact on public opinion Facebook X (Twitter) WhatsApp LinkedIn Pinterest Copy link The spread of digital disinformation 13/06/26, 16:19 Last updated: Published: 05/08/23, 11:06 IT cells and their impact on public opinion As of 2026, the internet boasts a staggering 5.66 billion estimated social media accounts, with a 4.8% year-on-year growth of +259 million users. The average person now spends 6 hours and 40 minutes daily connected to online screens, underscoring the significant role the internet plays in our lives. Consequently, it comes as no surprise that governments worldwide have recognised its potential as a critical tool to advance their agendas, policies, and achievements. Through diverse digital channels, governments aim to reach a vast audience and change public perception, striving to build transparency, trust, and legitimacy while maintaining a powerful digital presence. However, this approach also raises concerns about bias, propaganda, and information manipulation, which can impact public perceptions in questionable ways. One such phenomenon that has emerged is the presence of IT cells, organised groups typically affiliated with political parties, organizations, or interest groups. These Information Technology cells dedicate themselves to managing and amplifying their respective organisations' online presence, predominantly on social media platforms and other digital avenues. During contentious political events or national issues, IT cells deploy coordinated messaging in support of government policies and leaders, inundating social media platforms. Unfortunately, dissenting voices and critics may face orchestrated attacks from these IT cells, aimed at discrediting and silencing them. While some IT cells may operate with genuine intentions, they have faced criticism for engaging in tactics that spread misinformation, disinformation, and targeted propaganda to sway public sentiment in favour of their affiliated organisations. In such instances, IT cells strategically amplify positive news and government achievements while downplaying or deflecting negative information. Social media influencers and online campaigns have become tools to project a positive image of the government and maintain public support. One striking example of how governments can exploit IT cells for their gain was evident in the infamous Cambridge Analytica scandal. In 2018, revelations exposed how the political consulting firm, Cambridge Analytica, acquired personal data from millions of Facebook users without consent. The firm then weaponised this data to construct highly targeted and manipulative political campaigns, including during the 2016 United States presidential election and the Brexit referendum. In India, the ruling BJP party has come under scrutiny for its orchestrated online campaigns through its social media cell. The cell allegedly intimidates individuals perceived as government critics and actively disseminates misogyny, Islamophobia, and animosity. According to Sadhavi Khosla, a BJP cyber-volunteer associated with the BJP IT Cell, the organisation promotes divisive content and employs trolling tactics against users critical of the BJP. Journalists and Indian film actors have also found themselves targeted by these campaigns. As technology continues to evolve, it is imperative to strike a balance between leveraging the internet for transparency and legitimacy while safeguarding against potential misuse that could erode trust in digital governance and public discourse. Monitoring and addressing the activities of IT cells can be a significant step towards ensuring responsible and ethical use of digital platforms in the political arena. Written by Jaspreet Mann Related articles: COVID-19 misconceptions / Fake science websites Project Gallery

Synaptic plasticity is the process of connections within the brain changing to adapt to new information over time. It is of increasing significance in neuroscience, especially in the field of memory. Early research into synaptic plasticity was conducted by many of those Go Back Facebook X (Twitter) WhatsApp LinkedIn Pinterest Copy link Our understanding of how the brain forms connections between things we’ve learnt, and how London taxi drivers fit in Last updated: 01/03/26 Published: 05/01/23 Synaptic plasticity is the process of connections within the brain changing to adapt to new information over time. It is of increasing significance in neuroscience, especially in the field of memory. Early research into synaptic plasticity was conducted by many of those now considered the pioneers of neuroscience. For instance, Terje Lomo (1966) experimented on rabbit hippocampus with repeated, high-frequency stimulation, identifying long term potentiation, the persistent strengthening of synapses leading to enduring increases in signal transmission between neurons. Prior to work by Lomo, Ramon y Cajal (1911) proposed the idea that the strength of synaptic connections had to change to alter existing memories. One key question which is pertinent for both humans and other animals alike is how to keep track of our surroundings - how do our memories encode and store information on the places we visit so we can remember the directions for next time? Seminal work by Maguire et al., (2001) assessed whether physical changes “could be detected in the healthy brain” of London taxi drivers, given the repertoire of spatial experience required to navigate London without aid. Sixteen taxi drivers were studied with fifty controls. Using (structural) magnetic resonance imaging (MRI), it was found that taxi drivers’ posterior hippocampi were larger than that of control subjects, and the more experience the drivers had, the greater the size of their right posterior hippocampi. Such changes in tissue volume take place gradually over time, because of task-related training. Recent work by Spiers et al., (2022) looked at the difference in spatial navigational ability between city-dwellers and those living in rural areas. A subset of ~400,000 participants from 38 countries played a video game to test their skill in spatial navigation, with city-dwellers performing worse than those who grew up outside cities. More specifically, individuals were better at navigating in environments that were topologically like where they grew up. Hence, one interpretation of these results is that the place where a person grows up impacts their ability to accurately navigate new, unfamiliar environments since this is based on the synaptic connections made between existing information in the brain. In conclusion, synaptic plasticity is the change in connections in the brain over time; interest and research in this field, especially spatial navigation, are increasing significantly. Written by Manisha Halkhoree Full article published in Brain Insights- BNA Bulletin (Issue no. 96, Autumn 2022) Related articles: Brain plasticity / The wonders of the human brain / The brain-climate connection / Why brain injuries affect adults and children differently REFERENCES Nicoll, R. A Brief History of Long-Term Potentiation. Neuron. 2017 Jan 18; 93(2): 281-290. Available from: https://www.sciencedirect.com/science/article/pii/S0896627316309576 Maguire E, Gadian D, Johnsrude I, et. al. Navigation-related structural change in the hippocampi of taxi drivers. Proc Natl Sci U S A. 2000 Apr 11; 97(8): 4398–4403. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC18253/ Coutrot A, Manley E, Goodroe S., et. al. Entropy of city street networks linked to future spatial navigation ability. Nature. 2022 March 30; Nature 604: 104-110. Available from: https://www.nature.com/articles/s41586-022-04486-7

Sharpen your knowledge on this subject with articles dissecting the branch of behavioural economics (the role of honesty, endowment effect, loss of aversion, libertarian paternalism, effect of time), among others. Economics Articles Sharpen your knowledge on this subject with articles dissecting the branch of behavioural economics (the role of honesty, endowment effect, loss of aversion, libertarian paternalism, effect of time), among others. You may also like: Maths The role of honesty Article #1 in a series on behavioural economics The endowment effect Article #2 in a series on behavioural economics Loss aversion Article #3 in a series on behavioural economics Libertarian paternalism and the 'Nudge' approach Article #4 in a series on behavioural economics

Through photonic integration Facebook X (Twitter) WhatsApp LinkedIn Pinterest Copy link The future of semiconductor manufacturing 11/04/26, 15:43 Last updated: Published: 22/12/23, 15:11 Through photonic integration In December 2023, the researchers from the University of Sydney developed a compact photonic semiconductor chip by heterogeneous material integration methods which integrates an active electro-optic (E-O) modulator and photodetectors in a single chip. The chip functions as a photonic circuit (PIC) offering a 15 gigahertz of tunable frequencies with a spectral resolution of only 37 MHz and is able to expand the radio frequency bandwidth (RF) to precisely control the information flowing within the chip with the help of advanced photonic filter controls. The application of this technology extends to various fields: • Advanced Radar: The chip's expanded radio-frequency bandwidth could significantly enhance the precision and capabilities of radar systems. • Satellite Systems: Improved radio-frequency performance would contribute to more efficient communication and data transmission in satellite systems. • Wireless Networks: The chip has the potential to advance the speed and efficiency of wireless communication networks. • 6G and 7G Telecommunications: This technology may play a crucial role in the development of future generations of telecommunications networks. Microwave Photonics (MWP) is a field that combines microwave and optical technologies to provide enhanced functionalities and capabilities. It involves the generation, processing, and distribution of microwave signals using photonic techniques. An MWP filter is a component used in microwave photonics systems to selectively filter or manipulate certain microwave frequencies using photonic methods (see Figure 1 ). These filters leverage the unique properties of light and its interaction with different materials to achieve filtering effects in the microwave domain. They can be crucial in applications where precise control and manipulation of microwave signals are required. MWP filters can take various forms, including fiber-based filters, photonic crystal filters and integrated optical filters. These filters are designed to perform functions such as wavelength filtering, frequency selection and signal conditioning in the microwave frequency range. They play a key role in improving the performance and efficiency of microwave photonics systems. The MWP filter operates through a sophisticated integration of optical and microwave technologies as depicted in the diagram. Beginning with a laser as the optical carrier, the photonic signal is then directed to a modulator where it interacts with an input Radio-Frequency (RF) signal. The modulator dynamically influences the optical carrier's intensity, phase or frequency based on the RF input. Subsequently, the modulated signal undergoes processing to shape its spectral characteristics in a manner dictated by a dedicated processor. This shaping is pivotal for achieving the desired filtering effect. The processed optical signal is then fed into a photodiode for conversion back into an electrical signal. This conversion is based on the variations induced by the modulator on the optical carrier. The final output which is represented by the electrical signal reflects the filtered and manipulated RF signal which demonstrates the MWP's ability in leveraging both optical and microwave domains for precise and high-performance signal processing applications. Extensive research has been conducted in the field of MWP chips, as evidenced by a thorough examination in Table 1 . This table compares recent studies based on chip material type, filter type, on-chip component integration, and working bandwidth. Notably, previous studies demonstrated noteworthy advancements in chip research despite the dependence on external components. What distinguishes the new chip is its revolutionary integration of all components into a singular chip which is a significant breakthrough that sets it apart from previous attempts in the field. Here the term "On-chip E-O" involve the integration of electro-optical components directly onto a semiconductor chip or substrate. This integration facilitates the interaction between electrical signals (electronic) and optical signals (light) within the same chip. The purpose is to enable the manipulation, modulation or processing of optical signals using electrical signals typically in the form of voltage or current control. Key components of on-chip electro-optical capabilities include: 1. Modulators which alter the characteristics of an optical signal in response to electrical input which is crucial for encoding information onto optical signals. 2. Photonic detectors convert optical signals back into electrical signals extracting information for electronic processing. 3. Waveguides guide and manipulate the propagation of light waves within the chip, routing optical signals to various components. 4. Switches routes or redirects the optical signals based on electrical control signals. This integration enhances compactness, energy efficiency, and performance in applications such as communication systems and optical signal processing. "FSR-free operation" refers to Free Spectral Range (FSR) which is a characteristic of optical filters and resonators. FSR is the separation in frequency between two consecutive resonant frequencies or transmission peaks. The column "FSR-free operation" indicates whether the optical processing platform operates without relying on a specific or fixed Free Spectral Range. It means that its operation is not bound or dependent on a particular FSR. This could be advantageous in scenarios where flexibility in the spectral range or the ability to operate over a range of frequencies without being constrained by a specific FSR is desired. "On-chip MWP link improvement" refers to enhancements made directly on a semiconductor chip to optimize the performance of MWP links. These improvements aim to enhance the integration and efficiency of communication or signal processing links that involve both microwave and optical signals. The term implies advancements in key aspects such as data transfer rates, signal fidelity and overall link performance. On-chip integration brings advantages such as compactness and reduced power consumption. The manufacturing of the photonic integrated circuit (PIC) involves partnering with semiconductor foundries overseas to produce the foundational chip wafer. This new chip technology will play a crucial role in advancing independent manufacturing capabilities. Embracing this type of chip architecture enables a nation to nurture the growth of its autonomous chip manufacturing sector by mitigating reliance on international foundries. The extensive chip delays witnessed during the 2020 COVID pandemic underscored the global realisation of the chip market's significance and its potential impact on electronic manufacturing. Written by Arun Sreeraj Related articles: Advancements in semi-conductor technology / The search for a room-temperature superconductor / Silicon hydrogel lenses / Mobile networks Project Gallery

Julius Oppenheimer Facebook X (Twitter) WhatsApp LinkedIn Pinterest Copy link The chemistry of an atomic bomb 04/07/25, 13:57 Last updated: Published: 23/08/23, 17:29 Julius Oppenheimer Julius Robert Oppenheimer, often credited with leading the development of the atomic bomb, played a significant role in its creation in the early 1940s. However, it is essential to recognise the collaborative effort of many scientists, engineers, and researchers who contributed to the project. The history and chemistry of the atomic bomb are indeed fascinating, shedding light on the scientific advancements that made it possible. The destructive power of an atomic bomb stems from the rapid release of energy resulting from the splitting, or fission, of fissile atomic nuclei in its core. Isotopes such as uranium-235 and plutonium-239 are selected for their ability to undergo fission readily and sustain a self-sustaining chain reaction, leading to the release of an immense amount of energy. The critical mass of fissionable material required for detonation ensures that the neutrons produced during fission have a high probability of impacting other nuclei and initiating a chain reaction. To facilitate a controlled release of energy, neutron moderation plays a crucial role in the functioning of an atomic bomb. Neutrons emitted during fission have high velocities, making them less likely to be absorbed by other fissile material. However, by employing a moderator material such as heavy water (deuterium oxide) or graphite, these high-speed neutrons can be slowed down. Slowing down the neutrons increases the likelihood of their absorption by fissile material, enhancing the efficiency of the chain reaction and the release of energy. The sheer magnitude of the energy released by atomic bombs is staggering. For example, one kilogram (2.2 pounds) of uranium-235 can undergo complete fission, producing an amount of energy equivalent to that released by 17,000 tons (17 kilotons) of TNT. This tremendous release of energy underscores the immense destructive potential of atomic weapons. It is essential to note that the development of the atomic bomb represents a confluence of scientific knowledge and technological advancements, with nuclear chemistry serving as a foundational principle. The understanding of nuclear fission, the critical mass requirement, and the implosion design were key factors in the creation of the atomic bomb. Exploring the chemistry behind this devastating weapon not only provides insights into the destructive capabilities of atomic energy but also emphasises the responsibility that accompanies its use. In conclusion, while Oppenheimer's contributions to the development of the atomic bomb are significant, it is crucial to acknowledge the collective effort that led to its creation. The chemistry behind atomic bombs, from the selection of fissile isotopes to neutron moderation, plays a pivotal role in harnessing the destructive power of nuclear fission. Understanding the chemistry of atomic weapons highlights the remarkable scientific achievements and reinforces the need for responsible use of atomic energy. Written by Navnidhi Sharma Project Gallery