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Most research studies are now being diverted to Antiretroviral Therapy (ART) Facebook X (Twitter) WhatsApp LinkedIn Pinterest Copy link Antiretroviral therapy: a key to helping HIV patients 09/07/25, 10:51 Last updated: Published: 12/10/24, 11:34 Most research studies are now being diverted to Antiretroviral Therapy (ART) Human Immunodeficiency Virus, commonly called HIV, is a sexually transmitted disease that affects approximately 40 million people worldwide and is mostly common in ages 15-49 years. It is spread through direct contact with the blood, semen, pre-seminal fluid, and vaginal fluids of an infected person through mucous membranes—contact with male and female genital tracks. Additionally, HIV can be spread through breast milk from mother to child—studies have shown that infants likely contract the virus when the milk makes contact with the mucous membranes of the gut. How does HIV affect immune cells? HIV is a retrovirus—enveloped RNA viruses that can evade the immune defense system and live within host cells indefinitely. To infect cells HIV uses several mechanisms to make contact with the host cell's membrane. This involves the binding of HIV envelope protein (Env) with the cell receptor CD4 of an immune cell (T-helper cells). Env then binds to a co-receptor on the surface of the cell membrane, triggering membrane fusion. Membrane fusion leads to formation of a fusion pore where HIV successfully enters into the cell's cytoplasm through. Following this, HIV converts its RNA to DNA using enzyme reverse transcriptase and then uses integrase enzymes to become a permanent part of the host cell’s DNA. This allows HIV to replicate at a rapid rate, eventually causing the cells to bloat and rupture, killing the cell all while also “hiding” from the immune defense system and going into latency. Such a process is what weakens the immune system as there is a significant depletion in T-helper cells—cells that fight off infections and diseases. The evolution of ART For the reasons above, HIV is almost impossible to cure. While research is still being conducted to find a cure for HIV, most studies are now being diverted to Antiretroviral Therapy (ART). ART is a revolutionary treatment introduced in the late 198 0s that aims to prevent transmission of HIV, prolong survival, improve immune function and increase CD4 cell count, and improve overall mortality. The first drug released in the late 1980’s was Zidovudine, a nucleoside reverse transcriptase inhibitor (NRTI) that essentially prevents HIV’s RNA from being converted to DNA. This restricted replication hence increasing T-helper cell count. However, while shown to improve the condition of HIV patients, zidovudine did not work well on its own and caused drug resistance from prolonged use. Combination therapy was later introduced where scientists discovered zidovudine to be effective when used alongside another NRTI (dideoxycytidine). This combination did improve CD4 cell count and the overall condition of most patients, not in patients with advanced HIV who had prior use of zidovudine alone. Now, several medications such as NRTIs, non-nucleoside reverse transcriptase inhibitors (NNRTIs), protease inhibitors, and integrase inhibitors have been introduced and are used in a combination of three (Triple-Drug Therapy) to help suppress viral load to undetectable levels in the blood and improve the overall quality of life for patients. Triple-drug therapy can be tailored by doctors to improve the patient's condition. HIV is a sexually transmitted, chronic condition that affects less than 1% of the world's population. There is no cure for HIV, however, treatments (ART) have been introduced to reduce the viral load of HIV as well as improve the overall quality of life of patients. Compared to the past where these medications had to be taken multiple times a day, often causing severe side effects, patients can now take just a single tablet daily. This has changed the course of HIV treatment, allowing people to live lengthy, normal lives with the disease. Written by Sherine A Latheef Related article: CRISPR-Cas9 to potentially treat HIV REFERENCES Guha D, Ayyavoo V. Innate immune evasion strategies by human immunodeficiency virus type 1. ISRN AIDS . 2013;2013:954806. Published 2013 Aug 12. doi:10.1155/2013/954806 AlBurtamani N, Paul A, Fassati A. The Role of Capsid in the Early Steps of HIV-1 Infection: New Insights into the Core of the Matter. Viruses . 2021;13(6):1161. Published 2021 Jun 17. doi:10.3390/v13061161 Pau AK, George JM. Antiretroviral therapy: current drugs. Infect Dis Clin North Am . 2014;28(3):371-402. doi:10.1016/j.idc.2014.06.001 Mayers, Douglas L. “Prevalence and Incidence of Resistance to Zidovudine and Other Antiretroviral Drugs.” The American Journal of Medicine , vol. 102, no. 5, May 1997, pp. 70–75, https://doi.org/10.1016/s0002-9343(97)00067-3 . Accessed 5 Dec. 2021. “Antiretroviral Drug Discovery and Development | NIH: National Institute of Allergy and Infectious Diseases.” Www.niaid.nih.gov , www.niaid.nih.gov/diseases-conditions/antiretroviral-drug-development#:~:text=D urable%20HIV%20Suppression%20with%20Triple%2DDrug%20Therapy&text=In %20December%201995%2C%20saquinavir%20became. CDC. “How HIV Spreads.” HIV , 14 May 2024, www.cdc.gov/hiv/causes/index.html . clinicalinfo.hiv.gov . (n.d.). Protease Inhibitor (PI) | NIH . [online] Available at: https://clinicalinfo.hiv.gov/en/glossary/protease-inhibitor-pi . www.who.int . (n.d.). HIV . [online] Available at: https://www.who.int/data/gho/data/themes/hiv-aids#:~:text=Globally%2C%2039.9 %20million%20%5B36.1%E2%80%93. Project Gallery

Pathology and emerging therapeutics Facebook X (Twitter) WhatsApp LinkedIn Pinterest Copy link Bone cancer 09/07/25, 13:27 Last updated: Published: 12/10/23, 10:38 Pathology and emerging therapeutics Introduction: what is bone cancer? Primary bone cancer can originate in any b one. However, most cases develop in the long bones of the legs or upper arms. Each year, approximately 550 new cases are diagnosed in the United Kingdom. Primary bone cancer is distinct from secondary bone cancer, which occurs when cancer spreads to the bones from another region of the body. The focus of this article is on primary bone cancer. There are several types of bone cancer: osteosarcoma, Ewing sarcoma, and chondrosarcoma. Osteosarcoma originates in the osteoblasts that form bone. It is most common in children and teens, with the majority of cases occurring between the ages of 10 and 30. Ewing (pronounced as YOO-ing) sarcoma develops in bones or the soft tissues around the bones. Like osteosarcoma, this cancer type is more common in children and teenagers. Chondrosarcoma occurs in the chondrocytes that form the cartilage. Chondrosarcoma is most common in adults between the ages of 30 and 70 and is rare in the under-21 age group. Causes of bone cancer include genetic factors such as inherited mutations and syndromes, and environmental factors such as previous radiation exposure. Treatment will often depend on the type of bone cancer, as the specific pathogenesis of each case is unknown. What is the standard treatment for bone cancer? Most patients are treated with a combination of surgical excision, chemotherapy, and radiation therapy. Surgical excision is employed to remove the cancerous bone. Typically, it is possible to repair or replace the bone, although amputation is sometimes required. Chemotherapy involves using powerful chemicals to kill rapidly growing cells in the body. It is widely used for osteosarcoma and Ewing sarcoma but less commonly used for chondrosarcomas. Radiation therapy (also termed radiotherapy) uses high doses of radiation to damage the DNA of cancer cells, leading to the killing of cancer cells or slowed growth. Six out of every ten individuals with bone cancer will survive for at least five years after their diagnosis, and many of these will be completely cured. However, these treatments have limitations in terms of effectiveness and side effects. The limitation of surgical excision is the inability to eradicate microscopic cancer cells around the edges of the tumour. Additionally, the patient must be able to withstand the surgery and anaesthesia. Chemotherapy can harm the bone marrow, which produces new blood cells, leading to low blood cell counts and an increased risk of infection due to a shortage of white blood cells. Moreover, radiation therapy uses high doses of radiation, resulting in the damage of nearby healthy tissues such as nerves and blood vessels. Taken together, this underscores the need for a therapeutic approach that is non-invasive, bone cancer-specific, and with limited side effects. miR-140 and tRF-GlyTCC Dr Darrell Green and colleagues investigated the role of small RNAs (sRNAs) in bone cancer and its progression. Through the analysis of patient chondrosarcoma samples, the researchers identified two sRNA candidates associated with overall patient survival: miR-140 and tRF-GlyTCC. MiR-140 was suggested to inhibit RUNX2, a gene upregulated in high-grade tumours. Simultaneously, tRF-GlyTCC was demonstrated to inhibit RUNX2 expression by displacing YBX1, a multifunctional protein with various roles in cellular processes. Interestingly, the researchers found that tRF-GlyTCC was attenuated during chondrosarcoma progression, indicating its potential involvement in disease advancement. Furthermore, since RUNX2 has been shown to drive bone cancer progression, the identified miR-140 and tRF-GlyTCC present themselves as promising therapeutic targets. CADD522 Dr Darrell Green and colleagues subsequently investigated the impact of a novel therapeutic agent, CADD522, designed to target RUNX2. In vitro experiments have revealed that CADD522 reduced proliferation in chondrosarcoma and osteosarcoma. However, a bimodal effect was observed in Ewing sarcoma, indicating that lower levels of CADD522 promoted sarcoma proliferation, whereas higher levels of the same drug suppressed proliferation. In mouse models treated with CADD522, there was a significant reduction in cancer volumes observed in both osteosarcoma and Ewing sarcoma. Take-home message The results described here contribute to understanding the molecular mechanisms involved in bone cancer. They highlight the anti-proliferative and anti-tumoral effects of CADD522 in treating osteosarcoma and Ewing sarcoma. Further research is necessary to fully elucidate the specific molecular mechanism of CADD522 in bone cancer and to identify potential side effects. Written by Favour Felix-Ilemhenbhio Related articles: Secondary bone cancer / Importance of calcium / Novel neuroblastoma driver for therapeutics Project Gallery

Investigating the outbreak in Devon, UK in May 2024 Facebook X (Twitter) WhatsApp LinkedIn Pinterest Copy link Cryptosporidium: bridging local outbreaks to global health disparities 20/03/25, 12:06 Last updated: Published: 01/09/24, 12:50 Investigating the outbreak in Devon, UK in May 2024 In early May, news emerged of numerous Devon (UK) residents experiencing vomiting and diarrhoea. Majorly affecting the Brixham region, over 40 people were diagnosed with cryptosporidiosis, and over 16,000 homes were advised to boil water before consuming it to kill potential pathogens ( Figure 1 ). Despite a controversial handling of the situation from South West Water (SWW) (from initial denial of the ‘crisis’, to major profit increases for the company), the outbreak was eventually linked to a broken pipe from where animal faeces could have entered, contaminating the water supply, a SWW representative suggested. In this article, we will investigate the disease and its relevance worldwide. So, what is Cryptosporidiosis? Cryptosporidiosis is commonly associated with gastrointestinal symptoms, such as vomiting, diarrhoea and severe abdominal cramps. It is caused by cryptosporidium, from the Apicocomplexa family. This microorganism is an intra-cellular gut parasite which invades the microvilli in the gut and depletes host nutrients. The parasite is spread via faecal-oral transmission, and it is commonly found in contaminated water, food and animals. Its life cycle starts with oocyst (egg) ingestion, leading to attachment to host gut epithelia, and asexual reproduction. This allows sexual reproduction to ensue, and oocyst formation. Eventually, the oocysts are released via faeces, for the cycle of infection to continue. Cryptosporidium species are often identified by the immune system via Toll-Like Receptors, specifically TLR-4, in the gut epithelia; Cryptosporidium-derived molecules are treated as TLR-4 ligands, since the microbe does not produce LPS molecules. Adaptive immune signalling pathways, such as NF-kB, are triggered, encouraging IL-8, CXCL1 and other chemokine secretion from the gut ( Figure 2 ). Consequently, gut inflammation is increased, as well as levels of Intracellular Adhesion Molecule-1 (ICAM-1), to aid immunocyte recruitment and improve pathogenic clearance. Other mechanisms the epithelial barrier uses to eliminate cryptosporidium infection include NO secretion and mucin production, to kill the pathogen, and prevent further infection by blocking extracellular oocyst binding, respectively. In some individuals, cryptosporidium can evade immune response due to its intracellular nature. Most immunocompetent patients suffer mild symptoms and so are offered symptomatic treatment, but some immunocompromised patients (those with HIV, for example) can develop chronic diarrhoea as a result of cryptosporidium infection. In this instance, managing fluid loss and rest is often insufficient; these patients are prescribed nitazoxanide, a broad-spectrum antiparasitic, to manage their diarrhoea. Cryptosporidiosis on a global scale Although controversial, the management of the cryptosporidium ‘crisis’ in Devon was resolved relatively quickly compared to outbreaks in other countries ( Figure 3 ). There are clear links between socio-economic dynamics and water-borne illness prevalence. In some developing regions, such as areas in the Middle East and North Africa (MENA), cryptosporidiosis is considered endemic, due to poor quality water-sanitation centres, rapid population growth and inadequate potable water supply. Globally, 3.4 million people die each year from water-borne illnesses - and poor sanitation ranks higher in causes of human morbidity than war and terrorism. Additionally, in 2015, cryptosporidium was the fourth leading cause of death amongst children under 5, clearly highlighting the danger this parasite can cause. For children in developing countries, who are already predisposed to starvation, cryptosporidiosis can kick-start a malnutrition cycle. Here, cryptosporidium exacerbates host malnutrition due to its parasitic nature, potentially causing cognitive impairment and growth stunting. Cryptosporidiosis, although typically mild, can be devastating for some people (the immunocompromised and young children). Particularly, those who are malnourished can suffer severe effects. The water contamination in Devon (UK), handled by SWW, was unfortunate and many in the region experienced severe illness. Globally, cryptosporidiosis is a major problem and in some regions, it is considered endemic. Thus, it is important we spread awareness of the devastating effects of this disease, continue efforts to prevent transmission and strive for eradication. Written by Eloise Nelson REFERENCES Abuseir, S. (2023) ‘A systematic review of frequency and geographic distribution of water-borne parasites in the Middle East and North Africa’, Eastern Mediterranean Health Journal , 29(2), pp. 151–161. doi:10.26719/emhj.23.016. Chalmers, R.M., Davies, A.P. and Tyler, K. (2019) ‘Cryptosporidium’, Microbiology , 165(5), pp. 500–502. doi:10.1099/mic.0.000764. Hassan, E.M. et al. (2020) ‘A review of cryptosporidium spp. and their detection in water’, Water Science and Technology , 83(1), pp. 1–25. doi:10.2166/wst.2020.515. News, S. (2024) ‘Brixham: More than 50 people in Devon ill from contaminated water - as South West Water’s owner posts £166m profit’, Sky News , 21 May. Available at: https://news.sky.com/story/brixham-more-than-50-people-in-devon-ill-from-contaminated-water-as-south-west-waters-owner-posts-166m-profit-13140820#:~:text=More%20than%2050%20cases%20of,water%2C%20health%20bosses%20have%20said . Sparks, H. et al. (2015) ‘Treatment of cryptosporidium: What we know, gaps, and the way forward’, Current Tropical Medicine Reports , 2(3), pp. 181–187. doi:10.1007/s40475-015-0056-9. Caccio SM. Cryptosporidium : parasite and disease, Immunology of Cryptosporidiosis. Springer Verlag Gmbh; 2016. Project Gallery

Treatment based on the individual's genetics Facebook X (Twitter) WhatsApp LinkedIn Pinterest Copy link Personalised medicine 10/07/25, 10:28 Last updated: Published: 29/04/24, 10:44 Treatment based on the individual's genetics In modern medicine, the concept of genetic risk factors is well understood. Certain individuals will be predisposed to disease based on their family history and DNA. Similar to how we inherit traits like eye colour from our parents, susceptibility to conditions such as diabetes or cancer can also be inherited. However, it is only recently that we have begun to understand that an individual's genetic makeup will affect not only their risk for disease but also their reaction to treatment. Understanding risk factors is crucial for diagnosing disease and implementing preventative measures to maintain a patient's health. Utilising a person’s unique DNA could provide insights into their genetic predisposition towards different health conditions, thus accelerating the diagnostic process. Giving patients the ability to make informed decisions about their health based on their genetic risk could help them prevent disease. For example, women carrying the BRCA1 gene may opt for mastectomies to reduce the risk of breast cancer later in life. Personalised medicine doesn’t only focus on risk; it can also directly influence how treatments are administered. Genomic data can indicate which medicines are most likely to be effective and whether there may be associated side effects. The Human Genome Project has made tremendous advancements in the last decade. Combining this data with medical records could provide doctors with insights into the molecular-level interactions of different drugs with individual patients. Personalised medicine in practice Cancer serves as the best example of the importance of personalised medicine. Patients have a unique combination of risk factors from their DNA and lifestyle. However, the same treatments are often offered to everyone with the same type of cancer. The specific mutations that cause a cell to become cancerous are unique to each patient. The genetic makeup of cancer cells may determine which treatment should be focused on, and this is where personalised medicine plays a critical role. An example of personalised medicine already in use is for lung cancer, particularly for cancers with mutated Epidermal Growth Factor Receptors (EGFRs). EGFRs are surface proteins involved in cell growth and division. If there is a mutation, it can result in unpredictable and uncontrollable cell proliferation. There are drugs specifically designed to treat lung cancer cells carrying this EGFR mutation, with their mechanism of action based on this. These drugs would likely be ineffective for lung cancers with different mutations, as they have different mechanisms of action. Personalised medicine tailors treatment to the genetic makeup of a person to achieve a bespoke and hopefully improved outcome. Transcriptomics, the study of RNA and its alterations instead of DNA, may be a future avenue of investigation in understanding cancer biology. Tumours can arise due to mutated RNA or abnormal transcription events, indicating that DNA is not the only genetic material relevant to oncology. There have been promising innovations in personalised vaccines tailored to each patient. Tissue from an individual is biopsied and studied, and using identified biomarkers, a custom mRNA vaccine can prime the immune system to attack cancer cells. Future potential Genetic variation in a patient’s response to drugs can significantly affect their reactions to treatment. By combining genomic data and AI technology, scientists are developing predictive algorithms to create individualised medication plans for patients, potentially eliminating the guesswork in prescriptions. Personalised precision medication holds great potential. However, the primary limitation currently lies in the cost of treatment. Medical services are stretched thin across the population, making bespoke treatments currently unfeasible. Personalised medicine is expected to improve as new genetic biomarkers are discovered and catalogued, leading to more sophisticated genomic databases over time. As sequencing technology becomes more mainstream, associated costs are likely to decrease, possibly making personalised medicine standard practice in the future. Written by Charlotte Jones Related article: mRNA vaccines Project Gallery

Tesla’s vision was to develop wireless power across the globe Facebook X (Twitter) WhatsApp LinkedIn Pinterest Copy link Nikola Tesla, wireless electricity, and the failure of Wardenclyffe Tower 10/07/25, 10:25 Last updated: Published: 04/09/24, 10:37 Tesla’s vision was to develop wireless power across the globe Nikola Tesla Nikola Tesla (1856-1943) was a Serbian-American engineer and one of the most brilliant inventors of his time. His discoveries on how to utilise alternating current laid the foundation for the industrial revolution and today makes up the majority of power distribution systems globally. Finding inspiration from his mother Duka Mandic, whom he called a first-class inventor and credited for passing on her gift of discovery*, he went on to make significant contributions to the development of X-ray technology, radio, and robotics, as well as inventing the brushless AC motor, the rotating magnetic field, neon lights, and remote control. However, despite his many revolutionary inventions and around 300 patents to his name, Tesla died poor and ultimately failed in his greatest pursuit: to develop a free system of clean, wireless, electric power. Wardenclyffe Tower, also known as the Tesla Tower, was the first step in Tesla’s ‘World Wireless System’, a system designed to wirelessly broadcast electrical power across the globe, based on 20th century knowledge of resonance, the earth’s conductivity, and the Tesla coil. The Tesla coil: working principle The Tesla coil, invented by Nikola Tesla in 1894, is an alternating current resonant transformer that produces a high voltage from a low current. The high voltage produces sparks of ‘lightning’ or electrical discharge which can power lightbulbs. This experiment was a key motivator for Tesla’s later works with Wardenclyffe, although today the main use of the Tesla coil is for filming, entertainment, and educational displays. In a typical transformer, the ratio of turns determines the output voltage. The resonant properties of the secondary coil in a Tesla coil allows the transformer to achieve much higher voltages. A high voltage power supply from the first transformer is applied to a small primary coil, creating a large magnetic field. Current flow through the primary coil charges up a capacitor until the voltage across it exceeds the breakdown voltage of the spark gap (air). The capacitor discharges through the secondary coil in the opposite direction. This reverse current flow induces a magnetic field around the primary coil in the opposite direction. The constant changing of field direction induces a current in the secondary coil and produces a voltage proportional to the winding ratio of the coils. The resulting high voltage produces arcs of electricity similar to lightning from the terminal (typically torus shaped to direct sparks outward and prevent interference). Despite the high voltage, these electric discharges only produce a very small current in people who interact with it because of the high impedance of the coil and are not dangerous unless a person has a pacemaker or other medical device that could be affected by the high voltages. The frequency of the current has little interaction with nerve cells. Wardenclyffe Tower Following the same principles as the small-scale Tesla coil, Tesla’s vision was to replicate this on a large scale to develop wireless power across the globe, so that information could be transmitted from one tower to another by resonance. His early design featured two towers placed next to each other, so that the gap between the two domes could act as a spark gap. After cost revisions, the tower was redesigned to feature the entire transmitter circuit in one tower (see Figure 2 ). Figure 3 shows Tesla’s plan for the World Wireless System. An oscillator tower stands at 187 feet with a large dome of conductive metals on top, and an iron root system 300 feet into the earth. When the tower and Tesla receivers are tuned to the same resonant frequency, Tesla theorised that energy could be efficiently transferred between them. After obtaining funding from financier J.P. Morgan, Wardenclyffe tower began construction in 1901 in Shoreham, New York. The 187-foot tower featured a large spherical terminal, which was intended to ionize the atmosphere and create a conductive path for the energy. Below ground, a network of metal rods and plates would transmit energy into the Earth, relying on the Earth’s conductivity to complete the circuit. The working of the tower fundamentally relied on two highly under-researched principles, which were: 1. Earth as a conductor : In 1899 before Tesla began work on Wardenclyffe, he studied the periodicity of lightning in Colorado Springs, USA, and discovered what he called earth resonance. He found that large electrical impulses travel longitudinally through the earth to the antipode and are reflected (i.e., ‘resonate’) creating terrestrial stationary waves. He planned to use the tower to send electrical energy through the ground, which would then be picked up by receivers located anywhere on the planet. 2. Air as a conductor: Although air is normally a good insulator, at high altitudes (the earth’s ionosphere) it becomes an excellent conductor of high frequencies and voltages. The tower was designed to generate extremely high-frequency alternating currents, however reaching the earth’s ionosphere would require an antenna of at least 15 miles tall. Tesla apparently discovered a way to bypass this but did not make his methods public. There was very little knowledge about these phenomena at the time and even today are still not fully validated. Why Wardenclyffe failed Tesla initially pitched the project to J.P. Morgan as a world system of wireless communication to send messages, reports, and secure military messages, and to broadcast news and music. Morgan invested around $150,000 which Tesla accepted and instead began working on wireless electricity transmission, despite the investment being far below a realistic sum for the cost of the project. As Wardenclyffe tower required frequent modifications to the tower’s design during construction as well as expensive materials, the project was very costly. At the same time, Guglielmo Marconi achieved his less ambitious and inexpensive aim of wirelessly communicating the letter ‘s’ in Morse code (using some of Tesla’s patents). Combined with the Panic of 1907 and realising Tesla’s primary aim was for electricity to be free worldwide, which would be difficult to monetise, J.P. Morgan withdrew financial support and Tesla was forced to abandon the project. The scientific community and further potential investors were also sceptical about the feasibility of wireless energy transmission particularly considering energy losses over long distances, which made it difficult to obtain further funding. At the same time as Wardenclyffe Tower was being developed, Tesla’s AC power distribution system was being implemented rapidly. The established infrastructure of wired electricity transmission made it even more difficult for Tesla's wireless system to gain traction and funding, and the tower was demolished in 1917 to satisfy Tesla’s debts. Conclusion Wardenclyffe tower was an ambitious and audacious project which ultimately was not financially feasible. Even with modern day technology, efficiency, safety, and economic considerations prevent the system being a practical reality. Nevertheless, Tesla was undeniably an ingenious inventor, and his futuristic and daring approach to engineering continues to inspire innovations as well as debate. Today the site of Wardenclyffe tower is home to the Tesla Science Centre, a memorial to Tesla’s life and work. Footnotes * A highly skilled and intelligent woman despite no formal education, she invented various household tools and devices like the loom and egg whisk. Written by Varuna Ganeshamoorthy Related articles: Transformers / Mobile networks / Electricity in the body REFERENCE Tesla, N., & Johnston, B. (1982). My inventions: the autobiography of Nikola Tesla. Project Gallery

Discussing why people with PTSD have intrusive memories Facebook X (Twitter) WhatsApp LinkedIn Pinterest Copy link Boom, and You're Back! 09/07/25, 13:28 Last updated: Published: 19/01/24, 12:14 Discussing why people with PTSD have intrusive memories This is Part I in a two-part series on PTSD and intrusive memories. Next article: PTSD and Tetris Post-traumatic stress disorder (PTSD) is an anxiety disorder which may develop if a person has been involved in or witnessed a stressful event. Whilst most people associate PTSD with soldiers, it also develops in people like you and me. In fact, many events that lead to PTSD development occur in everyday life, such as car crashes, traumatic childbirth, assaults, robberies etc. One of the main symptoms of PTSD is intrusive memories. This is when people involuntarily develop recollections of the event within their consciousness. Dual modality theory The main model which explains the development of intrusive memories in PTSD is the Dual Representation Theory. This idea suggests that there are two separate memory systems which encode information during an event. The verbally accessible memory system (VAM) holds information about the conscious experience of the event meaning it can be voluntarily recalled afterwards. This is compared to the situationally accessible memory system (SAM) which processes unconscious sensory information, like smells and sounds, which cannot be voluntarily recalled. The theory suggests VAM is impaired and focuses on the frightening information and the fear that we experience during an event, and this effects how we process the information. Coupled with the vivid sensory information captured by SAM, when individuals are in a context where physical or sensory features are like the traumatic event, they unconsciously trigger intrusive memories which are highly distressing and emotionally valanced. Think of the last movie you watched about someone returning from war who was scared of fireworks. Now you understand that the banging sound triggers the highly emotional memories from the SAM and VAM system, forcing them to re-witness situations where a bomb has gone off. One loud boom and they are back in a war zone. Where in the brain is this going on? There are many brain areas involved in PTSD memory processing, but some common areas are associated with the formation and retrieval of traumatic memories. Hippocampus: combines lots of information in the environment into one memory that can be consciously retrieved. It seems likely that this area is essential for creating verbally accessible memories in trauma, so is part of the VAM system. Ventromedial prefrontal cortex: involved in regulating how much emotion is encoded into a memory. It has been said that dysfunction in this area is why people with PTSD have difficulties processing the emotion attached to the traumatic event. Amygdala: Important in how we learn to associate stimuli with the correct emotional response. It has been said in highly stressful events the amygdala becomes hyperactive which is why there is such a strong emotional reaction to certain cues, therefore is likely to be crucial in the SAM system. Hormones: elevated levels of glucocorticoids, cortisol, and norepinephrine can influence the consolidation of memories which creates stronger and more persistent traumatic memories. Written by Alice Jayne Greenan Related articles: Synaptic plasticity / Can you erase your memory? Project Gallery

For this experiment, the gravitational acceleration was calculated by measuring the time period of a simple pendulum using three different experimental methods; methods 2 and 3 were more similar than method 1. This experiment is primarily for data analysis of the measurements taken of a simple pendulum oscillating freely to determine the acceleration due to gravity. Go back Facebook X (Twitter) WhatsApp LinkedIn Pinterest Copy link Outline of an investigation of the period of a single pendulum, and its relation to gravity Last updated: 13/11/24 Last updated: 26/01/23 For this experiment, the gravitational acceleration was calculated by measuring the time period of a simple pendulum using three different experimental methods; methods 2 and 3 were more similar than method 1. This experiment is primarily for data analysis of the measurements taken of a simple pendulum oscillating freely to determine the acceleration due to gravity. This experiment can be repeated but can be carried out in different viscous liquids to see how the extra damping force affects the time period of the oscillation and calculate the g value from it. This can be useful to know as then making pendulum watches to work, say in different environments (such as under water), will be easier to make. It has future implications in industries and/ or technologies that produce related devices. Overall, this experiment was flawed from the beginning from not correctly applying the small angle criteria (in methods 2 and 3). However, there was success for method 1. (Reduced from a full lab report) Written by Siam Sama Related article: Viscosity of castor oil experiment

A chemist's palette Facebook X (Twitter) WhatsApp LinkedIn Pinterest Copy link The story of pigments and dyes 14/07/25, 15:05 Last updated: Published: 20/11/23, 11:05 A chemist's palette Pigments and dyes are vital in producing vibrancy and changing colours in our surroundings. Their vast use in cosmetics, pharmaceuticals, inks and textiles makes them important in playing a crucial role in creating the colourful world we see around us. But how do they come into existence? It all started from the extraction of colours from the world around us, such as green chlorophyll found in leaves and reds from berries. They were used to decorate caves and clothes in early civilization. However, when synthetic dyes came into play in the 19th century, things took an advance. Mauveine was accidentally discovered by William Henry Perkin; its vivid purple colour proved that we could make complicated organic substances from simpler ones, challenging the idea that organic compounds could only come from living things or nature. How does chemistry relate to the colours produced? Well, the way molecules are built fundamentally decides what colours are visible. In summary, the colours we see are a result of electrons in atoms and molecules absorbing and then releasing energy in the form of light. The specific colours are determined by the amount of energy released and the unique arrangement of electrons in each substance. In chemistry, pigments and dyes are used in various applications such as indicators in chemical reactions, chromatography, photovoltaic cells and most commonly in titration. They enable researchers to explore chemical processes and analyse substances. However, there are many environmental concerns regarding synthetic dyes, with pollution and water contamination. Synthetic dyes may also contain chemicals and additives that are toxic to aquatic life, posing risks to the environment. To address these issues, regulations, research into eco-friendly alternatives, sustainable practices, and educating people on this is important. In essence, we are constantly reminded of the evolving relationship between colours and chemistry. In the future, as more materials change colours and new uses are discovered, chemists will continue to be fascinated by the endless possibilities. Written by Anam Ahmed Project Gallery

Book review Facebook X (Twitter) WhatsApp LinkedIn Pinterest Copy link 'Intern Blues' by Robert Marion, M.D. 08/07/25, 14:33 Last updated: Published: 01/09/24, 12:30 Book review The public's glimpse of a doctor’s life varies depending on the doctor. Popular TV shows like Grey’s Anatomy , New Amsterdam , and Private Practice allow keen viewers to follow the romanticised lives of doctors, from their heroic moments to the romances and tragedies that take place in their hospital shifts. Similarly, social media platforms have been filled with doctors and medical students glamourising their experience with hashtags and filters, focusing on the positive but hardly ever commenting on their negative experiences. Additionally, flashy news articles celebrate a doctor’s innovative and ground-breaking methods and attempts to save a lucky patient’s life. In particular, doctors were placed in the spotlight during the COVID-19 pandemic, being seen as the real-life superheroes of the pandemic. On the other hand, in 2023, the televised NHS doctors’ protests presented the struggles and hardships endured by the professionals. Furthermore, a report by the General Medical Council in 2022 found that 50% of doctors were unhappy in their workplace. Simply put, the public’s perspective towards medicine and a doctor’s life will differ depending on their source and possibly their personal experiences. Therefore, how can one understand the world through the eyes of a doctor without studying and working within the profession? This question may never have a perfect answer, but the book Intern Blues by Robert Marion could be considered a step in the right direction. This book explores the life of three first-year interns (Amy, Adam, and Mark) in New York paediatric hospitals during the mid-1980s. After meeting his new interns and learning about the fear and outsider syndrome they felt toward the coming year, Dr. Robert Marion encouraged them to document their experiences during their year as interns to reflect and possibly learn through their achievements and struggles. Unknowingly, Dr Marion’s advice created the concept behind this inspiring book. The book explains treatment methods, their reasoning, and the medical abbreviations, making any reader feel like a doctor. This is emphasised by the vividly descriptive writing and the constant log of emotions, allowing anyone to experience the vibrant rush of a hospital from the comfort of their home. One of the best things about this book is each intern’s contrasting perspectives on such supposedly similar experiences. The first intern, Andy Baron, explored his struggles of living far from his family and girlfriend due to his awkward working hours and his feelings that his loved ones do not understand what he is going through. On the other hand, Amy Horowitz has an intriguing perspective of being a mother of a young child, presenting to the reader the struggles with viewing her own child in her patients' eyes and how she surpassed this challenge to succeed in her work. In contrast, Mark Greenberg has an interesting and almost humoristic negative perspective towards his experience – one should note that, at times, some of his entries are quite shocking with their abruptness and pessimistic view. On the other hand, one of the few limitations to note in this book would be the timing. Having taken place in the 1980s, the reader should note that some elements have changed and evolved over the years. However, one could argue that this difference in 40 years gives a uniqueness to the book as it allows for a comparison and reflection on how medicine has changed. For instance, there is a brief exploration of the struggle that Amy faced as a doctor: struggles that in some way stem from how being a woman made others view her differently from her male colleagues. Although these same struggles may not apply to female doctors in the present, the Amys of 2024 encounter their own challenges. Moreover, the book provides an interesting reflection on how the HIV pandemic changed medicine and forced the medical community to adapt – which, for many readers, can resonate with the recent COVID-19 pandemic. Intern Blues is an entertaining read that will make its readers want to hug their siblings and appreciate their lives differently. This book will elicit laughs, tears, and moments of profound contemplation - a rollercoaster of emotions filled to the brim with intriguing medical cases. Presenting the hardships these three doctors faced, one has the opportunity to reflect and decide for themselves: does the good outweigh the bad? What causes the balance to tip? Is a doctor’s life made for them? Nevertheless, one conclusion is constant: the newfound admiration for the healthcare community. Check out this book on Amazon Written by Inês Couto André Related article and book review: Healthcare serial killers / The Emperor of All Maladies REFERENCES Marion R. The Intern Blues: The Timeless Classic about the Making of a Doctor. Reprint edition. William Marrow & Company; 2001. General Medical Council. The State of Medical Education and Practice in the UK, Workplace Experiences 2023 [Internet]. General Medical Council. 2023 June. Available from: gmc-uk.org/stateofmed . Project Gallery

...In the nerve fibre world Facebook X (Twitter) WhatsApp LinkedIn Pinterest Copy link Squids are size champions 11/07/25, 09:53 Last updated: Published: 29/06/23, 09:33 ...In the nerve fibre world A cephalopod adventure When you think of squids, you probably imagine them swimming through the ocean and using tentacles to catch their prey. Scientists might not! These slimy sea creatures have helped us to study and understand how our own nervous system works. That’s right, squids are more than just tasty seafood. Squids have a giant axon, which is a single nerve fiber that is much larger than the axons found in other animals, including humans. This giant axon can be up to one millimeter in diameter , which is big enough to be seen with the naked eye. If you’re thinking that 1 millimeter is still pretty small, consider that human axons are measured in micrometers (µm) , so the squid’s giant axons are almost one thousand times larger in diameter than ours . In case you’re wondering what an axon is, it’s the long projection of a neuron that conducts electrical impulses away from the cell body. The electrical impulses generated during an action potential travel down the axon and make their way to the synapse. So the axon is a vital component of the nervous system that helps facilitate communication between neurons and other cells. In 1963, the English scientists Hodgkin and Huxley were awarded the Nobel Prize for their groundbreaking experiments on squid giant axons. Through their work, they provided a detailed understanding of the electrical properties of axon membranes and the role of ion channels in generating and propagating nerve impulses. They also discovered that the giant axon is surrounded by a thick layer of insulation called myelin , which speeds up the transmission of nerve impulses. Their research has been fundamental to the development of modern neurophysiology. So, the next time you enjoy a plate of calamari, remember that the squid on your plate might have contributed to our understanding of the nervous system. Written by Viviana Greco Related article: Frog nerves Project Gallery