Search Index

Resources such as: other websites, textbooks, YouTube videos, and books to help! Aiding university students studying STEM subjects. Extra Resources A masterlist of other websites, textbooks, YouTube videos, and books to help with your studies, research and revision. You may also like: A-level resources, IB resources, Entrance exam preparation, FREE CV and PS checks!, STEM book reviews Representation in STEM Sisterhood in STEM GENERAL INFORMATION Referencing guide: Cite Them Right Cite this for me ZoteroBib (fast, free reference generator) Phrasebank to help with essays Free notes and textbooks: Studocu Grammar checker: Grammarly (available as a browser extension) Money financing for students: Save the Student Others: New Scientist (print and online magazine) BBC iPlayer science and nature documentaries WEBSITES TO AID STUDIES Science and maths: MME Revise Cognito Resources Access Tuition Maths Genie LibreTexts: biology , chemistry , physics , maths , engineering , and medicine HELP WITH RESEARCH Databases: - PubMed - MEDLINE (by National Library of Medicine) - ScienceDirect - Web of Science - Literature search: Google Scholar - Participate in actual research: Zooniverse - citizen science - Top multi-disciplinary journal in the field: Nature PHARMACOLOGY AND RELATED Reference sites: - Pharmgkb - Drug Bank - Check which drugs are in trial Textbooks: - Katzung's Basic & Clinical Pharmacology, 16th edition by Todd Vanderah, PhD - The Top 100 Drugs: Clinical Pharmacology and Practical Prescribing by Andrew Hitchings, Daniel Burrage, Dagan Lonsdale and Emma Baker BIOLOGICAL SCIENCES TEXTBOOKS Biology: - Campbell & Reece - Molecular biology and genetics: Molecular Biology of the Cell. 4th edition - Molecular Cell Biology by Lodish et al - Anatomy and physiology: Marieb - Principles of Animal Physiology by Moyes and Schulte - Animal Physiology by Hill, Wyse, and Anderson - Developmental Biology by Barresi and Gilbert - Cancer: The Biology of Cancer by Robert A. Weinberg Biochemistry: - Medical Biochemistry b y N. Mallikarjuna Rao Neuroscience: - Purves et. al - Kandel Immunology: - Immunobiology, 5th edition The Immune System in Health and Disease Genetics: - Emery's Elements of Medical Genetics and Genomics by Turnpenny & Ellard - Lewin’s Genes by Krebs, Goldstein, and Kilpatrick - Human Molecular Genetics by Strachan and Read CHEMISTRY TEXTBOOKS Physical chemistry: - Atkins Physical Chemistry (latest edition) - Solid State Chemistry (Fourth Edition) by Lesley Smart and Elaine Moore Organic chemistry: - Jonathan Clayden Organic Chemistry (latest edition) Inorganic chemistry: - Atkins Physical Chemistry (latest edition) - Housecroft Inorganic Chemistry (latest edition) - Electronic Structure (Basic Theory and Practical Methods) by Richard M. Martin - Two-minute Neuroscience - Amoeba Sisters (biology related) - Khan Academy (all STEM based) - TEDx Talk - Royal Society (range of science videos) - NumberPhile - patrickJMT (maths) - Tyler DeWitt (general chemistry) - Crash Course - Stanford Medicine (wellness) PHYSICS Resources: - Astronomy Picture of the Day - NASA STEM activities Textbooks: - University Physics by Young and Freedman - Introduction to Electrodynamics by Griffiths - Introduction to Elementary Particles by Griffiths - Introduction to Quantum Mechanics by Griffiths - Modern Quantum Mechanics (Third Edition) by J. J. Sakurai and Jim Napolitano - Introductory Statistical Mechanics by Bowley & Sanchez - Statistical Mechanics: A Survival Guide by Glazer & Wark - Electricity and Magnetism by Morin and Purcell - Concepts in Thermal Physics by Blundell and Blundell - Introduction to Solid State Physics by Mittel & McEuen - Solid State Physics by Ashcroft and Mermin - Space, Time, and Geometry by Sean M. - Density Functional Theory by David S. Sholl and Janice A. Steckel - The Physics of Semiconductors: An Introduction Including Nanophysics and Applications by Marius Grundmann - Quantam Field Theory for the Gifted Amateur by Tom Lancaster & Stephen J. Blundell - Condensed Matter Field Theory (Second Edition) by Alexander Altland and Ben Simons - Condensed Matter Physics by Michael P. Marder MATHS Textbooks: - Mathematical Methods for Physicists and Engineers by Riley Benson and Hobson - Mathematics for Natural Scientists 1 and 2 by Lev Kantorovich - Advanced Engineering Mathematics by Kreyszig - Thomas's Calculus by George B. Thomas - Mathematical Methods for Science students by G Stephenson - Contemporary Abstract Algebra by Joseph A. Gallian Read this article on how to excel in maths COMPUTER SCIENCE AND RELATED Resources: - Codeacademy - W3Schools ( has tutorials for HTML/ CSS/ Javascript, Python, Java, and many other languages) - Adacomputerscience - TeachComputing - Codewars (practise coding with your friends) - freeCodeCamp ENGINEERING Resources: - eFunda- formulae - Engineering statistics handbook - The Engineering Toolbox - free tools, calculators, and more - Engineers Edge - Online Ethics - ethics in engineering and science PSYCHOLOGY Resources: - QMUL resource guides - Psychology Today - Royal Holloway activities and research - Verywell Mind INFORMATIVE YOUTUBE CHANNELS

Unlocking the mystery of spinal disorders and paving the way for targeted therapies Facebook X (Twitter) WhatsApp LinkedIn Pinterest Copy link Unveiling the cancer magnet: vertebral stem cells and spinal tumour metastasis Last updated: 29/05/25, 10:46 Published: 24/04/25, 07:00 Unlocking the mystery of spinal disorders and paving the way for targeted therapies Introduction Researchers at Weill Cornell Medicine have discovered that the vertebral bones in the spine contain a unique type of stem cell that secretes a protein-promoting tumour metastasis. This protein, called MFGE8, plays a significant role in attracting tumours to the spine, making it more susceptible to metastasis when compared to other bones in the body. A new line of research on spinal disorders This groundbreaking study , published in the journal Nature, sheds light on the mechanisms behind the preference for solid tumours to spread to the spine. The findings open up a new line of research on spinal disorders, potentially leading to a better understanding and treatment of bone diseases involving the spine. Identifying vertebral stem cells The researchers began their study by isolating skeletal stem cells, which are responsible for bone and cartilage formation, from various bones in lab mice. Through gene activity analysis, they identified a distinct set of markers for vertebral stem cells. Further experiments in mice and lab-dish cell culture systems confirmed the functional roles of these stem cells in forming spinal bone. Unravelling the mystery of spinal tropism Previous theories attributed the spine's susceptibility to metastasis to patterns of blood flow. However, the study's findings challenged this long-standing belief. Animal models reproduced the phenomenon of spinal tropism, but the researchers discovered that blood flow was not the sole explanation. Instead, they found evidence pointing towards vertebral stem cells as the possible culprits. The role of MFGE8 The researchers discovered that spinal tropism is largely a result of the protein MFGE8, which vertebral stem cells secrete in greater quantities than other bone stem cells. Removing vertebral stem cells eliminated the difference in metastasis rates between spine bones and other long bones. Implications for cancer patients These findings have significant implications for cancer patients, particularly those at risk of spinal metastasis. The researchers are now exploring methods to block the activity of MFGE8, aiming to reduce the risk of tumour spread to the spine. By understanding the distinctive properties of vertebral stem cells, researchers hope to develop targeted treatments for spinal disorders. A new frontier in orthopaedics According to study senior author Matthew Greenblatt, the identification of these unique stem cells opens up a new subdiscipline in orthopaedics called spinal orthopaedics. Many conditions in this clinical category may be attributed to the properties of vertebral stem cells. Further research in spinal orthopaedics is needed to understand how these distinct properties of vertebral stem cells contribute to spinal disorders. The discovery of MFGE8, a protein secreted in higher amounts by vertebral stem cells, has shed light on the mechanism behind the preferential spread of tumours to the spine. By investigating methods to block MFGE8, researchers hope to reduce the risk of spinal metastasis in cancer patients. Additionally, the study findings highlight the importance of understanding the role of vertebral stem cells in bone diseases that primarily affect the spine. This new line of research may provide insights into the development of novel treatments for spinal disorders. Conclusion In conclusion, the study by researchers at Weill Cornell Medicine has shown that vertebral bones, which make up the spine, contain a particular type of stem cell that secretes a protein known as MFGE8. This protein plays a significant role in promoting tumour metastases, explaining why solid tumours often spread to the spine. The findings have opened up new avenues of research in understanding spinal disorders and may lead to the development of strategies for reducing the risk of spinal metastasis in cancer patients. Overall, this study highlights the importance of vertebral stem cells in contributing to spinal disorders and emphasises the need for further investigation in this field. Written by Sara Maria Majernikova Related articles: Cancer metastasis / Brain metastasis / Stem cells REFERENCE Sun, J., Hu, L., Bok, S. et al. A vertebral skeletal stem cell lineage driving metastasis. Nature 621, 602–609 (2023). https://doi.org/10.1038/s41586-023-06519-1 Project Gallery

Decoding diversity in clinical settings Facebook X (Twitter) WhatsApp LinkedIn Pinterest Copy link Solving the mystery of ancestry with SNPs and haplogroups 10/02/25, 14:37 Last updated: Published: 15/01/24, 19:47 Decoding diversity in clinical settings Single nucleotide polymorphisms (SNPs) are genetic variants whereby one DNA base becomes substituted for another between individuals or populations. These tiny but influential changes play a pivotal role in defining the differences between populations, affecting disease susceptibility, response to medications, and various biological traits. SNPs serve as genetic markers and are widely used in genetic research to understand the genetic basis of complex traits and diseases. With advancements in sequencing technologies, large-scale genome-wide association studies (GWAS) have become possible, enabling scientists to identify associations between specific SNPs and various phenotypic traits. Haplotypes refer to clusters of SNPs commonly inherited together, whereas haplogroups refer to groups of haplotypes commonly inherited together. Haplogroups are frequently used in evolutionary genetics to elucidate human migration routes based on the ‘Out of Africa’ hypothesis. Notably, the study of mitochondrial and Y-DNA haplogroups has helped shape the phylogenetic tree of the human species along the female line. Haplogroup analysis is also instrumental in forensic genetics and genealogical research. Additionally, haplogroups play a crucial role in population genetics by providing valuable insights into the historical movements of specific populations and even individual families. Certain SNPs in some genes are of clinical importance as they may either increase or decrease the likelihood of developing a particular disease. An example of this is that men belonging to haplogroup I have a 50% higher likelihood of developing coronary artery disease 1 . This predisposition is due to SNPs present in some Y chromosome genes. Cases like these highlight the possibility of personalised medical interventions based on an individual’s haplogroup and therefore, SNPs in their genome. In this case, a treatment plan of exercise, diet, and lifestyle recommendations can be given as preventative measures for men of haplogroup I to mitigate genetic risk factors before they develop the disease. Written by Malintha Hewa Batage REFERENCE https://www.sciencedirect.com/science/article/pii/S002191501300765X?via%3Dihub [02/12/2023 - 14:53] Project Gallery

The Design Argument vs science Facebook X (Twitter) WhatsApp LinkedIn Pinterest Copy link The Anthropic Principle: Science or God? 20/11/25, 15:34 Last updated: Published: 08/11/24, 11:25 The Design Argument vs science One of the most common points of tension between science and religion is the Design Argument – an argument for the existence of an intelligent designer/creator of the universe or God. Individuals who tend to identify with one of the Abrahamic religions (Christianity, Judaism, and Islam) often also believe in a God who created the universe, although it is important to note that not every person agrees here. On the other hand, public opinion often says that scientists do not support the Design Argument because they are studying how the universe was ‘actually’ created, which leads to some tension between the two groups. However, there is some logical support for the Design Argument originating from scientific data: the Anthropic Principle, also known as the Observation-Selection Hypothesis. While there are different takes on the hypothesis, this article will briefly cover how it relates to physics and the Design Argument. In general, the Anthropic Principle states that the parameters of the universe are exactly what they are so that life (intelligent, conscious life) would ultimately be produced. The following are examples of factors that happen to be just right for life to be possible: The electromagnetic force is 39 times stronger than gravity, but if they were more evenly matched, stars would not survive long enough for life to develop on an orbiting planet. If gravity were 1 part in 1040 stronger, the universe would have utterly collapsed long ago. If the combined mass of a proton and electron were slightly more than the mass of a neutron (rather than slightly less as it currently is), then the hydrogen atom would become unstable, which would collapse stars like the Sun. If the mass of neutrinos (the most abundant particles with mass in the universe) was 5 x 10-34 kg instead of 5 x 10-35 kg, the universe would be contracting rather than expanding. There are many more examples, but isn’t it strange how absolutely exact the strengths of these kinds of fundamental forces are? This is the line of reasoning that leads to the Design Argument. How could the universe be so incredibly exact to produce life, unless it was specifically created that way? Such questions are asked by Science and Religion scholars, and while there are no answers yet, it opens the conversation up to explore what information different fields have to offer. Written by Amber Elinsky Related article: Creatio ex Nihilo REFERENCES Davis, John Jefferson. “The Design Argument, Cosmic ‘Fine Tuning,’ and the Anthropic Principle.” International Journal for Philosophy of Religion 22, no. 3 (1987): 139–50. http://www.jstor.org/stable/40018832 . Gale, George. “The Anthropic Principle.” Scientific American 245, no. 6 (1981): 154–71. http://www.jstor.org/stable/24964627 . Project Gallery

The science behind tooth decay Facebook X (Twitter) WhatsApp LinkedIn Pinterest Copy link How to prevent tooth decay 10/04/25, 10:52 Last updated: Published: 03/02/24, 11:24 The science behind tooth decay Dental caries, commonly referred to as tooth decay, manifests as a gradual process and progressive disease affecting the dental hard tissues, resulting in the breakdown of tooth structure and the potential for pain and infection within the oral cavity. Understanding the mechanisms behind tooth decay is crucial for adopting effective preventative measures, to stop or reverse the carious process and prevent cavity formation. Several factors contribute to dental caries, including bacteria, time, fermentable carbohydrates, and a susceptible tooth surface. In the absence of regular toothbrushing, a plaque biofilm is allowed to form on the tooth surface—a sticky, colourless film that serves as a breeding ground for bacteria such as Streptococcus mutans and Lactobacillus species. Once these bacterial species encounter fermentable carbohydrates and sugars from our diet, they begin to metabolise them, producing acids as a by-product. These acids contribute to an acidic environment in the mouth. When enamel, the outermost layer of tooth structure, is exposed to an acidic pH below 5.5, its mineral structure weakens, initiating the dissociation of hydroxyapatite crystals. Frequent acid attacks from dietary sugars result in a net mineral loss in teeth, leading to cavity formation, dental pain, and potential infections. The initial stage of decay involves the demineralisation of enamel. At this point, the damage can be reversible with good oral hygiene practices and through remineralising agents. Saliva has the capacity to remineralise initial carious lesions, and fluoride application through fluoridated toothpaste can also aid in reversing the initial stages of dental caries. However, if left untreated and allowed to progress, the decay can develop further into the tooth structure reaching the softer dentine beneath enamel. Dentin decay occurs more rapidly than enamel and can contribute to increased sensitivity and discomfort. As the decay advances, it may reach the dental pulp, which is the nerve of the tooth. Infection of the pulp can trigger severe pain and may necessitate root canal treatment in attempt to save the tooth. Persistent infections can lead to abscess formation—a pocket of pus causing swelling, pain, and systemic health issues, should the infection spread throughout the body. Tooth decay can be preventing through regular brushing with a fluoride toothpaste. The consistent disturbance to the plaque biofilm formation through brushing it away will not allow the caries process to continue, and hence prevent cavity formation. The fluoride aspect will help to strengthen the enamel and remineralise any mineral loss found in early lesions; this can stop and even reverse the carious process, thus preventing dental decay A healthy diet with limited consumption of sugary foods and drinks can significantly reduce the risk of tooth decay; with less sugars in the oral environment there is a lower rate of bacterial metabolisation to create the acids which contribute to the decay process. Regular dental check up appointments enable early detection and intervention of any initial lesions, preventing the progression of decay before reaching an irreversible status. Tooth decay is a preventable yet prevalent oral health issue. Instigated by the action of oral bacteria metabolising sugars in the mouth, our natural tooth structure can be destructed and decayed if the plaque biofilm is not controlled. By understanding the causes and progression of tooth decay, individuals can adopt proactive measures to maintain good oral hygiene, preserve enamel, and safeguard their smiles for a lifetime. Regular dental check-ups and a commitment to a healthy lifestyle play pivotal roles in preventing the onset and progression of tooth decay. Written by Isha Parmar Related article: Importance of calcium REFERENCE (Banerjee & Watson, 2015): Banerjee, A. and Watson, T.F. (2015) Pickard’s Guide to Minimally Invasive Operative Dentistry, King’s College London. Project Gallery

The closest planet to the Sun Facebook X (Twitter) WhatsApp LinkedIn Pinterest Copy link Exploring the solar system: Mercury 09/07/25, 14:08 Last updated: Published: 27/06/23, 15:46 The closest planet to the Sun Mercury, the closest planet to the Sun, holds a significant place in our understanding of the solar system and serves as our first stepping stone in the exploration of the cosmos. Its intriguing history dates back to ancient times when it was studied and recorded by the Babylonians in their celestial charts. Around 350 BC the ancient Greeks, recognized that the celestial body known as the evening and morning star was, in fact, a single entity. Impressed by its swift movement, they named it Hermes, after the swift messenger of their mythology. As time passed, the Roman Empire adopted the Greek discovery and bestowed upon it the name of their equivalent messenger god, Mercury, a name by which the planet is known today. This ancient recognition of Mercury's uniqueness paved the way for our continued exploration and study of this fascinating planet. Mercury's evolution As Mercury formed from the primordial cloud of gas and dust known as the solar nebula, it went through a process called accretion. Small particles collided and gradually merged together, forming larger bodies called planetesimals. Over time, these planetesimals grew in size through further collisions and gravitational attraction, eventually forming the protoplanet that would become Mercury. However, the proximity to the Sun presented unique challenges for Mercury's formation. The Sun emitted intense heat and powerful solar winds that swept away much of the planet's initial atmosphere and surface materials. This process, known as solar stripping or solar ablation, left behind a relatively thin and tenuous atmosphere compared to other planets in the solar system. The intense heat also played a crucial role in shaping Mercury's surface. The planet's surface rocks melted and differentiated, with denser materials sinking towards the core while lighter materials rose to the surface. This process created a large iron-rich core, accounting for about 70% of the planet's radius. Mercury's lack of significant geological activity, such as plate tectonics, has allowed its surface to retain ancient features and provide insights into the early history of our solar system. The planet's surface is dominated by impact craters, much like the Moon. These craters are the result of countless collisions with asteroids and comets over billions of years. The largest and most prominent impact feature on Mercury is the Caloris Basin, a vast impact crater approximately 1,525 kilometres in diameter. The impact of such large celestial bodies created shockwaves and volcanic activity, leaving behind a scarred and rugged terrain. Scientists estimate that the period known as the Late Heavy Bombardment, which occurred around 3.8 to 4.1 billion years ago, was particularly tumultuous for Mercury. During this time, the inner planets of our solar system experienced a high frequency of cosmic collisions. These impacts not only shaped Mercury's surface but also influenced the evolution of other rocky planets like Earth and Mars. Studying Mercury's geology and surface features provides valuable insights into the early stages of planetary formation and the impact history of our solar system. Exploration history Our understanding of Mercury has greatly benefited from a series of pioneering missions that ventured close to the planet and provided valuable insights into its characteristics. Let's delve into the details of these key exploratory endeavours: Mariner 10 (1974-1975): Launched by NASA, Mariner 10 was the first spacecraft to conduct a close-up exploration of Mercury. It embarked on a series of three flybys, passing by the planet in 1974 and 1975. Mariner 10 captured images of approximately 45% of Mercury's surface, revealing its heavily cratered terrain. The spacecraft's observations provided crucial information about the planet's rotation period, which was found to be approximately 59 Earth days. Mariner 10 also discovered that Mercury possessed a magnetic field, albeit weaker than Earth's. MESSENGER (2004-2015): The MESSENGER mission, short for Mercury Surface, Space Environment, Geochemistry, and Ranging, was launched by NASA in 2004. It became the first spacecraft to enter into orbit around Mercury in 2011, marking a significant milestone in the exploration of the planet. Over the course of more than four years, MESSENGER conducted an extensive study of Mercury's surface and environment. It captured detailed images of previously unseen regions, revealing the planet's diverse geological features, including vast volcanic plains and cliffs. MESSENGER's data also indicated the presence of water ice in permanently shadowed craters near Mercury's poles, surprising scientists. Furthermore, the mission discovered that Mercury possessed a global magnetic field, challenging previous assumptions about the planet's magnetism. MESSENGER's observations greatly expanded our knowledge of Mercury's geology, composition, and magnetic properties. BepiColombo (2018-Present): The BepiColombo mission, a joint endeavour between the European Space Agency (ESA) and the Japan Aerospace Exploration Agency (JAXA), aims to further enhance our understanding of Mercury. The mission consists of two separate orbiters: the Mercury Planetary Orbiter (MPO) developed by ESA and the Mercury Magnetospheric Orbiter (MMO) developed by JAXA. Launched in 2018, BepiColombo is currently on its journey to Mercury, with an expected arrival in 2025. Once there, the mission will study various aspects of the planet, including its magnetic field, interior structure, and surface composition. The comprehensive data collected by BepiColombo's orbiters will contribute significantly to our knowledge of Mercury and help answer remaining questions about its formation and evolution. These missions have played pivotal roles in advancing our understanding of Mercury. They have provided unprecedented insights into the planet's surface features, composition, magnetic field, and geological history. As exploration efforts continue, we can anticipate further revelations and a deeper understanding of this intriguing world. Future exploration While significant advancements have been made in understanding Mercury, there is still much more to learn. Scientists hope to explore areas of the planet that have not yet been observed up close, such as the north pole and regions where water ice may be present. They also aim to study Mercury's thin atmosphere, which consists of atoms blasted off the surface by the solar wind. Moreover, the advancement of technology may lead to the development of innovative missions to Mercury. Concepts such as landing missions and even manned exploration have been proposed, although the challenges associated with the planet's extreme environment and proximity to the Sun make such endeavours highly demanding. Nevertheless, the quest to unravel Mercury's mysteries continues, driven by the desire to deepen our knowledge of planetary formation, evolution, and the unique conditions that shaped this enigmatic world. Exploring the uncharted areas of Mercury, particularly the north pole, holds great scientific potential. The presence of water ice in permanently shadowed regions has been suggested by previous observations, and investigating these areas up close could provide valuable insights into the planet's volatile history and the potential for water resources. Additionally, studying Mercury's thin atmosphere is of significant interest. Comprised mostly of atoms blasted off the surface by the intense solar wind, understanding the composition and dynamics of this atmosphere could shed light on the processes that shape Mercury's exosphere. In conclusion, while significant progress has been made in unravelling the mysteries of Mercury, there is still much to explore and discover. Scientists aspire to investigate untouched regions, study the planet's thin atmosphere, and employ innovative mission concepts. The future may hold ambitious missions, including landing missions and potentially even manned exploration. As our knowledge and capabilities expand, Mercury continues to beckon us with its fascinating secrets, urging us to push the boundaries of exploration and expand our understanding of the wonders of the solar system. And with that we finish our journey into the history and exploration of Mercury and will move to Venus in the next article. Written by Zari Syed Related articles: Fuel for the colonisation of Mars / Nuclear fusion Project Gallery

How botox works in the cosmetic industry Facebook X (Twitter) WhatsApp LinkedIn Pinterest Copy link From botulism to beauty: the evolution of botulinum toxins and botox 09/07/25, 14:10 Last updated: Published: 03/10/23, 14:07 How botox works in the cosmetic industry Botulinum neurotoxins (BoNTs) rank amongst the most potent and lethal neurotoxins known to science. Yet, it's a fascinating journey to discover how these deadly substances have found their way into one of the most renowned cosmetic procedures in the world: Botox. BoNTs originate from the bacterium Clostridium botulinum , which produces some of the most potent neurotoxins in existence. They are central to the development of botulism, a condition that relentlessly targets the body's nervous system, resulting in challenges in breathing and muscle paralysis. Despite their perilous origins, these toxins have undergone a fascinating metamorphosis into a popular cosmetic procedure. They have been studied substantially due to their ability to block nerve functions leading to muscle paralysis and their unique pharmacological properties in therapeutic and cosmetic uses. They affect the neurotransmission process by blocking the release of acetylcholine that allows muscle contraction in the body. The toxins bind pre-synaptically to recognition sites on cholinergic nerve terminals resulting in the inhibition of neurotransmitter release. The toxin consists of a heavy chain and a light chain connected by a disulphide bond. This disulphide bond is vital in the entry of the metalloprotease chain in the cytosol. BoNTs have a unique binding characteristic as a dual receptor binder, which allows them to achieve a high affinity for neurons. These proteins possess the remarkable ability to specifically target and interfere with the neurotransmission process. At their core, BoNTs are proteases, enzymes specialised in cleaving specific proteins involved in nerve signal transmission. When administered as Botox, BoNTs are skillfully harnessed to their advantage due to these properties. By injecting small, controlled amounts into specific facial muscles, they temporarily disrupt the nerve signals that stimulate muscle contraction. This action leads to muscle relaxation, smoothing out wrinkles and lines on the skin's surface. Importantly, the effects are localised, preserving the natural expressiveness of the face. In 1989, BoNTs made their debut in the medical community by being recognised as a safe and effective treatment by the FDA for blepharospasm, which affects eye muscle control. However, in 2002 the FDA extended its endorsement, propelling Botox into the realm of beauty. This pivotal decision forever reshaped the landscape of cosmetic procedures, solidifying Botox's status as an iconic treatment for rejuvenation and enhancement. In conclusion, the evolution of botulinum toxins and the rise of Botox is a captivating journey that traverses the realms of science, medicine, and evolving beauty ideals. Written by Anam Ahmed Project Gallery

It's produced by European honeybees Facebook X (Twitter) WhatsApp LinkedIn Pinterest Copy link Medicinal Manuka 10/07/25, 10:21 Last updated: Published: 11/05/24, 10:57 It's produced by European honeybees Manuka honey has received considerable attention recently due to its impressive antimicrobial ability and potential for future clinical use. Manuka honey is produced by European honeybees ( Apis mellifera ) that visit the Manuka tree ( Leptospermum scoparium ) in New Zealand. It is most commonly distributed as monofloral honey (produced by bees that have visited predominantly one plant species—in this case, the Manuka bush); however, it can also be sold as multifloral. The Manuka tree, which the European honeybees visit, has a long history of use for its medicinal properties. The Māori (the indigenous Polynesian people of mainland New Zealand) valued it for its wide variety of uses, referring to the plant as ‘taonga’ (‘treasure’). The leaves from the tree were used to make infusions that could reduce fevers, and the gum produced from the tree was used to moisturise burns and soothe coughs. In the 18th century, European settlers contacted the Māori and became aware of this tree and its healing properties; they used the leaves as a medicinal tea to treat scurvy. In 1839, an English beekeeper, Mary Bumby, introduced bees to New Zealand, and by 1860, the bee population had grown extensively, and colonies were present throughout forests. The Māori learnt to harvest the honey produced by these bees and promoted the production of Manuka honey. The honey was used by the Māori for the same benefits they used the Manuka tree. In the 1980s, the biochemist Peter Molan launched the first scientific research on the antimicrobial properties of Manuka honey, evaluating its ability to kill microbes. Research has demonstrated that Manuka honey is an effective bactericidal (killer of microbes). Dr Jonathon Cox and his colleagues at Aston University showed that administering Manuka honey can be effective against Mycobacterium abscessus , which is fatal without treatment. Using a model of an artificial lung, Dr Cox found that the addition of Manuka honey reduced the dosage of the highly potent amikacin by 8-fold, which is an extremely significant difference to the quality of life of patients as a common consequence of the 13-month amikacin treatment is permanent hearing loss. Alternative remedies for bacterial infections are required to combat the growing concern of antibiotic resistance. Many molecules of Manuka honey are responsible for their antimicrobial activity, including methylglyoxal (MGO) content. MGO can interfere with the lipid bilayer structure of the bacterial membrane, leading to leakage of its cellular contents and cell death. MGO can also impair the function of enzymes involved in energy production and macromolecule synthesis within bacteria. Additionally, Manuka honey can also produce hydrogen peroxide, which generates highly reactive oxygen species (ROS) within bacterial cells. These ROS, such as hydroxyl radicals, can cause oxidative damage to biomolecules, including proteins, lipids, and DNA, leading to bacterial cellular death. Altogether, these mechanisms enable Manuka honey to disrupt bacterial growth and proliferation. Manuka honey is currently used as a medical product for professional wound care in European hospitals. The main advantage of Manuka honey is that the mechanisms behind its antibacterial activity are diverse, making it effective against resistant strains of bacteria, including methicillin-resistant Staphylococcus aureus (MRSA) . A systematic review written by Jonathon Cox states that certain commercially available varieties of Manuka honey are effective against organisms that have a high degree of antibiotic resistance. Therefore, this leads to the promising preliminary conclusion that Manuka honey could be the answer to the investigation of finding an effective antimicrobial, an alternative to antibiotics. Written by Harvey Wilkes Related article: Natural substances as treatment to infection REFERENCES Nolan, V.C., Harrison, J. and Cox, J.A., 2022. In vitro synergy between manuka honey and amikacin against Mycobacterium abscessus complex shows potential for nebulisation therapy. Microbiology, 168(9), p.001237. Nolan, V.C., Harrison, J., Wright, J.E. and Cox, J.A., 2020. Clinical significance of manuka and medical-grade honey for antibiotic-resistant infections: a systematic review. Antibiotics , 9 (11), p.766. Project Gallery

Nanoparticles have unique properties Facebook X (Twitter) WhatsApp LinkedIn Pinterest Copy link Nanoparticles: the future of diabetes treatment? 17/07/25, 10:52 Last updated: Published: 06/05/24, 13:20 Nanoparticles have unique properties Diabetes mellitus is a chronic metabolic disorder affecting millions worldwide. Given its myriad challenges, there is a substantial demand for innovative therapeutic strategies in its treatment. The global diabetic population is expected to increase to 439 million by 2030, which will impose a significant burden on healthcare systems. Diabetes occurs when the body cannot produce enough insulin, a hormone crucial for regulating glucose levels in the blood. This deficiency leads to increased glucose levels, causing long-term damage to organs such as the eyes, kidneys, heart, and nervous system, due to defects in insulin function and secretion. Nanoparticles have unique properties making them versatile in their applications and are promising to help revolutionise the future of the treatment of diabetes. This article will explore the potential of this emerging technology in medicine and will address the complexities and issues that arise with the management of diabetes. Nanoparticles have distinct advantages: biocompatibility, bioavailability, targeting efficiency and minimal toxicity, making them ideal for antidiabetic treatment. The drug delivery is targeted, making the delivery precise and efficient, avoiding off-target effects. Modifying nanoparticle surfaces enhances therapeutic efficacy, enabling targeted delivery to specific tissues and cells, while reducing systemic side effects. Another currently researched key benefit is real-time glucose sensing and monitoring, which addresses a critical aspect in managing diabetes, as nanoparticle-based glucose sensors can detect glucose levels with high sensitivity and selectivity. This avoids the use of invasive blood sampling and allows for continuous monitoring of glucose levels. These can be functionalised and integrated into wearable devices, or implanted sensors, making it convenient and reliable to monitor and to be able to optimum insulin therapy. Moreover, nanoparticle-based approaches show potential in tissue regeneration, aiding insulin production restoration. For example, in particular, nanomedicine is a promising tool in theranostics of chronic kidney disease (CKD), where one radioactive drug can diagnose and a second delivers the therapy. The conventional procedure to assess renal fibrosis is by taking a kidney biopsy, which is then followed by a histopathological assessment. This method is risky, invasive, and subjective, and less than 0.01 % of kidney tissue is examined which results in diagnostic errors, limiting the accuracy of the current screening method. The standard use of pharmaceuticals has been promising but can cause hypoglycaemia, diuresis, and malnutrition because of the low caloric intake. Nanoparticles offer a new approach to both diagnosis and treatment and are an attractive candidate for managing CKD as they can carry drugs and enhance image contrast, controlling the rate and location of drug release. In the treatment of this multifaceted disease, nanoparticle delivery systems seem to be a promising and innovative therapeutic strategy, with the variety in the methods of delivery. The range of solutions that are currently being developed are promising, from enhancing the drug delivery to monitoring the glucose level, to direct tissue regeneration. There is immense potential for the advancement of nanomedicines, helping improve patient outcomes, the treatment efficacy, and allowing the alleviation of the burden and side effects of the disorder. With ongoing efforts and innovation, the future treatment of diabetes can be greatly helped with the use of nanoparticles, and these advancements will improve strategies for the management and future treatment of diabetes. Written by Saanchi Agarwal Related articles: Pre-diabetes / Can diabetes mellitus become an epidemic? / Nanomedicine / Nanoparticles on gut health / Nanogels / Nanocarriers REFERENCES Lemmerman LR, Das D, Higuita-Castro N, Mirmira RG, Gallego-Perez D. Nanomedicine-Based Strategies for Diabetes: Diagnostics, Monitoring, and Treatment. Trends Endocrinol Metab. 2020 Jun;31(6):448-458. doi: 10.1016/j.tem.2020.02.001. Epub 2020 Mar 4. PMID: 32396845; PMCID: PMC7987328. Dehghani P, Rad ME, Zarepour A, Sivakumar PM, Zarrabi A. An Insight into the Polymeric Nanoparticles Applications in Diabetes Diagnosis and Treatment. Mini Rev Med Chem. 2023;23(2):192-216. doi: 10.2174/1389557521666211116123002. PMID: 34784864. Luo XM, Yan C, Feng YM. Nanomedicine for the treatment of diabetes-associated cardiovascular diseases and fibrosis. Adv Drug Deliv Rev. 2021 May;172:234-248. doi: 10.1016/j.addr.2021.01.004. Epub 2021 Jan 5. PMID: 33417981. L. Tillman, T. A. Tabish, N. Kamaly, A. El-Briri F, C. Thiemermann, Z. I. Pranjol and M. M. Yaqoob, Review Advancements in nanomedicines for the detection and treatment of diabetic kidney disease, Biomaterials and Biosystems, 2022, 6, 100047. J. I. Cutler, E. Auyeung and C. A. Mirkin, Spherical nucleic acids, J Am Chem Soc, 2012, 134, 1376–1391. Veiseh, O., Tang, B., Whitehead, K. et al. Managing diabetes with nanomedicine: challenges and opportunities. Nat Rev Drug Discov 14, 45–57 (2015). https://doi.org/10.1038/nrd4477 Project Gallery

From the Big Bang to the current model Facebook X (Twitter) WhatsApp LinkedIn Pinterest Copy link Story of the atom 11/02/25, 12:23 Last updated: Published: 20/04/24, 11:16 From the Big Bang to the current model The Greek philosopher and physicist Democritus proposed the idea of an atom at around 440 B.C. The atom is first explained by him using a stone. When a stone is split in half, it becomes two separate stones. There would eventually come to be a portion of the stone that would be too small to be cut if it were to be cut continuously i.e., indivisible. Since then, many scientists have adopted, discarded, or published their own theories about the nature, structure, and size of atoms. However, the most widely accepted, and still the basic model used to study atoms is Rutherford’s model. Rutherford published his theory of the atom suggesting that it had an electron orbiting a positively charged nucleus. This model was created after a series of experiments which included shooting alpha particles at thin gold sheets. Most of the alpha particles flowed through with little disturbance, but a tiny fraction was scattered at extreme angles to their initial direction of motion. Rutherford calculated the estimated size of the gold atom's nucleus and discovered that it was at least 10,000 times smaller than the atom's total size, with a large portion of the atom made up of empty space. This theory paved the way to further the atomic models by various other scientists. (Figure 1) Researchers have discovered unidentified molecules in space which are believed to be the precursor of all chemistry in the universe. The earliest "atoms" in the cosmos were actually nuclei without any electrons. The universe was incredibly hot and dense in the earliest seconds following the Big Bang. The quarks and electrons that make up matter first appeared when the cosmos cooled, and the ideal conditions were met for them to do so. Protons and neutrons were created by quarks aggregating a few millionths of a second later. These protons and neutrons joined to form nuclei in a matter of minutes. (Figure 2) Things started to happen more slowly as the cosmos cooled and expanded. The first atoms were formed 380,000 years ago when electrons were locked into orbits around nuclei. These were mostly hydrogen and helium, which are still the elements that are found in the universe in the greatest quantities. Even now, the most basic nucleus, found in ordinary hydrogen, is only a single, unadorned proton. There were other configurations of protons and neutrons that also developed, but since the number of protons in an atom determines its identity, all these other conglomerations were essentially just variations of hydrogen, helium, and lithium traces. To say that this is an exciting time for astrochemistry is an understatement. Furthermore, the formation mechanism of amino acids and nucleobases is being demonstrated by laboratory simulations of interstellar environments. Now that we are finding answers to these known problems, even more are arising. Hopefully, a more thorough understanding of these chemical processes will enable us to make more precise deductions about the general history of the universe and astrophysics. Written by Navnidhi Sharma REFERENCES CERN (n.d.). The early universe. [online] CERN. Available at: https://home.cern/science/physics/earlyuniverse#:~:text=As%20the%20universe%20continued%20to . Compound Interest (2016). The History of the Atom – Theories and Models | Compound Interest. [online] Compound Interest. Available at: https://www.compoundchem.com/2016/10/13/atomicmodels/ . Fortenberry, R.C. (2020). The First Molecule in the Universe. Scientific American. [online] doi: https://doi.org/10.1038/scientificamerican0220-58 . Sharp, T. (2017). What is an Atom? [online] Live Science. Available at: https://www.livescience.com/37206-atom-definition.html . Project Gallery