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Contributions include artificial radioactive atoms, atomic structure, ribosome research Facebook X (Twitter) WhatsApp LinkedIn Pinterest Copy link Female Nobel Prize Winners in Chemistry 02/05/25, 11:30 Last updated: Published: 03/06/23, 17:37 Contributions include artificial radioactive atoms, atomic structure, ribosome research Women contributing their innovative ideas has strengthened the knowledge held in the scientific world. It is important to realise that women in STEM need to be celebrated all year round – they need to be given the recognition they deserve. A total of 60 women have been awarded the Nobel Prize between 1901 and 2022. Specifically looking at the Female Nobel Prize winners in Chemistry – all of whom have changed the way society views women but also puts a spotlight on the progress that can still be made if we have more women in the field of STEM. There have been eight women to receive this prestigious award: Carolyn R. Bertozzi, Emmanuelle Charpentier, Jennifer A. Doudna, Frances H. Arnold, Ada E., Dorothy Crowfoot Hodgkin, Yonath, Irène Joliot-Curie and Marie Curie. This article celebrates their ground-breaking discoveries and contributions to the world of science and is a way to serve as an inspiration to young girls and women in the hope to raise a generation where more women are studying STEM subjects and acquiring high-ranked roles to reduce the gender gap. Nobel Prizes won in- 2022: Carolyn R. Bertozzi was awarded for her development of biorthogonal reactions which has allowed scientists to explore and track biological processes without disrupting the chemistry of the original cells. 2020: Emmanuelle Charpentier and Jennifer Doudna were awarded for their development of a method for high-precision genome editing: CRISPR/Cas9 genetic scissors. They used the immune system of a bacterium, which disables viruses by cutting their DNA up with a type of genetic scissors. The CRISPR/Cas9 genetic scissors has led to many exciting discoveries and new ways to fight against cancer and genetic diseases. 2018: Frances Arnold was awarded because of her work on directed evolution of enzymes. In 1993, Arnold conducted the first directed evolution of enzymes, which are proteins that catalyse chemical reactions. This has led to the manufacturing of environmentally friendly chemical substances such as pharmaceuticals, and the production of renewable fuels. 2009: Ada Yonath was awarded the Nobel Prize for her studies on the structure and functions of the ribosome. In the 1970s, Ada began a project that concluded in her successful mapping of the structure of ribosomes, which consisted of thousands of atoms, using x-ray crystallography. This has been important in the production of antibiotics. 1964: Dorothy Hodgkin was awarded the 1964 Nobel Prize in Chemistry for solving the atomic structure of molecules such as penicillin and insulin, using X-ray crystallography. 1935: Irène Joliot-Curie was awarded for her discovery that radioactive atoms could be created artificially. Written by Khushleen Kaur Related articles: Female Nobel prize winners in physics / African-American women in cancer research Project Gallery

Resources to help you prepare for university admission. Entrance Exam Preparation Resources to help you with university admission for: medicine , dentistry, natural sciences , physics , maths , engineering . Do note these entrance exams are mainly for UK universities, but can be used for international unis too. It is advised to check with the university when applying. You may also like: A-level resources, IB resources and Extra resources MEDICINE: University Clinical Aptitude Test (UCAT) UCAT resources: UCAT website / The Medic Portal / 6med UCAT Books: 1300 UCAT Practice Questions / 1250 UKCAT Practice Questions / UCAT 700+ UCAT online course: Medify Help with medical exams DENTISTRY: UCAT and BioMedical Admissions Test (BMAT; for University of Leeds only) Dentistry application preparation BMAT: online mastery course / Medify guide / Past papers / 700 BMAT Practice Questions / BMAT ebook For UCAT resources, see above OTHER ADMISSION TESTS Engineering: STEP / PAT University of Cambridge: natural sciences (NSAA) / engineering (ENGAA) / maths (STEP) / physics (PAT)

Resources specific to A-levels to help students with revision. A-levels Are you a student currently studying A-levels, or looking to choose them in the near future? Read below for tips and guidance! You may also like: IB resources , University prep and Extra resources What are A-levels? Jump to resources A-levels, short for Advanced Level qualifications, are a widely recognised and highly regarded educational program typically taken by students in the United Kingdom (UK) and some other countries. They are usually studied in the final two years of secondary education, typically between the ages of 16 and 18. A-levels offer students the opportunity to specialise in specific subjects of their choice. Students typically choose three or four subjects to study, although this may vary depending on the educational institution. The subjects available can be diverse, covering areas such as sciences, humanities, social sciences, languages, and arts. How are A-levels graded? The A-level grading system is based on a letter grade scale in the UK. Here's an overview of the A-level grading system: Grades: A* (pronounced "A-star"): The highest grade achievable, demonstrating exceptional performance. A: Excellent performance, indicating a strong understanding of the subject. B: Very good performance, showing a solid grasp of the subject. C: Good performance, representing a satisfactory level of understanding. D: Fair performance, indicating a basic understanding of the subject. E: Marginal performance, showing a limited understanding of the subject. U: Ungraded, indicating that the student did not meet the minimum requirements to receive a grade. What are the benefits of studying A-level? A-levels provide students with a variety of advantages, such as a solid academic foundation for further education, the chance to focus on interest-specific areas, and flexibility in planning their course of study. Transferable abilities like critical thinking, problem-solving, and independent research are developed in A-levels, improving both prospects for entrance to universities and future employment opportunities. These widely respected credentials encourage intellectual vigour, intellectual curiosity, and a love of lifelong study. A-levels provide students with a strong foundation for success in higher education and a variety of career pathways, thanks to their academic rigour and global renown. Resources for revision Web sites to hel p Maths / Maths and Further Maths Chemistry / Chemrevise / Chemguide Biology / Quizzes Physics: A-level Physics / Isaac Physics Computer Science topic-by-topic Teach Computer Science Psychology All subjects / Seneca Learning / Save My Exams Physics and Maths Tutor YouTube channels to hel p Chemistry- Allery Chemistry and Eliot Rintoul Past p apers Biology, Chemistry, Physics, Maths Textbooks (depend on exam board) CGP range for Bio, Chem, Phys, and Maths- exam practice workbooks

Comparative oncology Facebook X (Twitter) WhatsApp LinkedIn Pinterest Copy link What can our canine friends tell us about cancer? 21/02/25, 12:32 Last updated: Published: 02/07/24, 10:04 Comparative oncology Comparative oncology is a field of study within cancer that has been adopted to study cancer and develop new therapies. It involves studying cancer in animals to uncover similarities between human and animal cancers. By combining scientific findings across a range of species, including companion animals such as dogs and horses or non-human primates such as monkeys, comparative oncology will advance cancer research and help develop effective novel therapies. This approach not only explores cancers in both animals and humans but also aims to bridge the gap between human and veterinary medicine. By examining similarities and differences in cancer biology, progression and treatment responses across species, comparative oncology provides valuable insights that can benefit both fields. Understanding how cancer behaves in animals can offer new perspectives and potential therapies for human patients. Conversely, while findings in human oncology can inform veterinary medicine, leading to improved diagnostics and treatments for animals. ( Figure 1 summarises the aims of comparative oncology). This article aims to explore this field of oncology further by discussing what it entails, the methodologies utilised, some recent advancements, and finally, things to look out for in the future. Comparative oncology has been developed and expanded into two areas of study. This includes spontaneous oncology and experimental oncology. Spontaneous oncology focuses on naturally occurring tumours in animals by investigating aspects of carcinogenesis, epidemiology, diagnosis, and treatment. It provides unique insights by drawing comparisons with human oncology research. These results can then be extrapolated to human oncology to gain a better understanding of cancer. This is because the similarities and differences observed in naturally occurring tumours across species provide valuable insights into underlying mechanisms within tumours and treatment responses. Experimental oncology serves as a distinct discipline where there are specialisations such as studying viral, chemical, and radiation oncogenesis alongside studying environmental factors such as pollution residues and food additives. This area involves studying both spontaneous tumours in animals and lab settings, where controlled conditions are used to explore different parts of cancer biology and treatment strategies. Additionally, the primary methodology utilised in comparative oncology involves studying spontaneous tumours in animals. Unlike artificially induced tumours in lab animals, these spontaneous tumours in pets closely mimic the complexity and heterogeneity of human cancers. For example, canines will live in similar living environments and experience similar external stimuli to their owner, such as pollution. The nature of these external stimuli means that they develop cancer in similar ways caused by epigenetic alterations, metabolic, and immune changes. (Figure 2 illustrates this process). Furthermore, comparative oncology uses advanced imaging techniques, genetic analysis, and immunological studies to predict pathways that may be shared among animals and humans which, could drive cancer development. Overall, these methods will allow the identification of promising therapies which directly target cancer and expand on current treatment choices such as chemotherapy and immunotherapy. One of the recent advancements in comparative oncology relates to osteosarcomas. This refers to cancer cells which begin to grow in the bones. For this specific form of cancer, molecular signatures were identified to predict clinical outcomes for both humans and canines, which can help improve treatment outcomes. Led by Amy K. LeBlanc, scientists have identified gene activity patterns in osteosarcoma tumours in nearly 200 dogs, revealing distinct groups with varying prognoses. These findings help us understand the biology behind osteosarcomas further and can potentially help us develop targeted therapies that take advantage of the immune system to treat the disease in both species. This potentially includes a range of therapies including PD-L1 inhibitors and cancer vaccines targeting the immune system. Moreover, breakthroughs in immunotherapies such as checkpoint inhibitors and CAR-T cell therapy are effective in treating haematological malignancies in both humans and canines. Furthermore, studies in canine melanoma reveal similar gene expression changes to human melanoma, such as in the PI3K/AKT/mTOR and MAPK pathways, even when the driver mutations are different. (Figure 3 shows how the pathway contributes to cancer). Useful data was provided in trials using companion animals with spontaneous tumours, providing an insight into safety, dosage, and efficacy, which have paved the way to develop treatments for both species. To conclude, it is clear with comparative oncology, researchers will be able to identify new molecular targets, assess novel drugs, and identify patient populations which will benefit the most from these therapies. It holds great promise in helping streamline cancer diagnosis further and even plays a role in preventing cancer. While the field shows great potential, more studies still need to be conducted to understand the similarities and differences in cancers between animals and humans. Additionally, more collaboration is needed amongst oncologists, veterinarians, and researchers across these disciplines to harness collective expertise to address questions relating to cancer diagnosis, treatment, and prevention. Ultimately, this field will help us identify new avenues of treating and diagnosing cancer whilst improving healthcare outcomes for humans and animals alike. Written by Harene Elayathamby Related articles: Why blue whales don't get cancer / Rare zoonotic diseases REFERENCES Schiffman, J.D. and Breen, M. (2015) ‘Comparative oncology: What dogs and other species can teach us about humans with cancer’, Philosophical Transactions of the Royal Society B: Biological Sciences , 370(1673), p. 20140231. doi:10.1098/rstb.2014.0231. Oh, J.H. and Cho, J.-Y. (2023) ‘Comparative oncology: Overcoming human cancer through companion animal studies’, Experimental & Molecular Medicine , 55(4), pp. 725–734. doi:10.1038/s12276-023-00977-3. Al, B. and C., C. (2007) ‘Chapter 1 COMPARATIVE ONCOLOGY ’, in Comparative oncology . Bucharest (RO): The Publishing House of the Romanian Academy, p. 1. Vail, D.M., LeBlanc, A.K. and Jeraj, R. (2020) ‘Advanced cancer imaging applied in the comparative setting’, Frontiers in Oncology , 10. doi:10.3389/fonc.2020.00084. New findings highlight shared features of human and canine osteosarcoma (2023) Center for Cancer Research . Available at: https://ccr.cancer.gov/news/article/new-findings-highlight-shared-features-of-human-and-canine-osteosarcoma (Accessed: 02 March 2024). Mochel, J.P. et al. (2018) Car T-cell immunotherapy in human and veterinary oncology: Changing the odds against hematological malignancies [Preprint]. doi:10.20944/preprints201811.0525.v1. LeBlanc AK, Mazcko CN, Khanna C. (2016) ‘Defining the Value of a Comparative Approach to Cancer Drug Development’, Clinical cancer research : an official journal of the American Association for Cancer Research , 22(9). p. 2133-2138. doi: 10.1158/1078-0432.CCR-15-2347 FIGURE REFERENCES Boddy, A.M., Harrison, T.M. and Abegglen, L.M. (2020) ‘Comparative oncology: New insights into an ancient disease’, iScience , 23(8), p. 101373. doi:10.1016/j.isci.2020.101373. Oh, J.H. and Cho, J.-Y. (2023) ‘Comparative oncology: Overcoming human cancer through companion animal studies’, Experimental & Molecular Medicine , 55(4), pp. 725–734. doi:10.1038/s12276-023-00977-3. Rascio, F. et al. (2021) ‘The pathogenic role of PI3K/Akt pathway in cancer onset and drug resistance: An updated review’, Cancers , 13(16), p. 3949. doi:10.3390/cancers13163949. Project Gallery

Is bacteria the key to unlocking this treatment? Facebook X (Twitter) WhatsApp LinkedIn Pinterest Copy link A breakthrough in endometriosis treatment 27/03/25, 12:05 Last updated: Published: 29/06/23, 09:16 Is bacteria the key to unlocking this treatment? In a giant leap forward, scientists have linked a specific bacterial infection to endometriosis for the very first time. Endometriosis is a condition in which the endometrium (lining of the uterus wall) grows outside of the uterus. For many women, the condition is characterised by debilitating pain, fatigue and infertility. The average time span for an accurate diagnosis is 7.5 years, with some women opting for a complete hysterectomy (removal of the uterus) to curb the pain. Unfortunately, the pathogenesis (the process by which a disease develops) of endometriosis is still relatively unknown. With previous scientific theories including retrograde menstruation, immune dysregulation, hormonal imbalance, stem cells and benign metastasis- this is the first time a bacterial theory has been forwarded. Dr Muraoka and his team theorised a link between bacterial localisation within the female reproductive tract and endometriosis- following promising research carried out on mice models. The Japanese study discovered a bacterium known as Fusobacterium to be present in the uteruses of 65% of women suffering from endometriosis, compared to less than 7% of women without the disease. Fusobacterium is a bacterium which is mostly found within the microbe of the mouth, gut and vagina. This bacterium has been linked to other inflammatory diseases such as gum disease. Follow-up studies- undertaken on mice- discovered that those treated with antibiotics saw a significant reduction in both size and frequency of lesions associated with the disease. Clinical trials are now forging ahead to investigate the effects of antimicrobials as a viable treatment option for endometriosis patients. This revolutionary study is the first of its kind and could see patient disease management progress away from medieval invasive procedures and decades of pain. For more information on Dr Muraoka and his team's work check out his study . Written by Kellie Leonard Related articles: Underreporting of endometriosis / Are PCOS and endometriosis sisters? / Gynaecology Project Gallery

An individual may be restricted to a certain range of physical activities which they can participate in. Individuals are usually reliant on the surrounding environment and the maintenance of facilities. If they are not kept well maintained, individuals are usually discouraged. Go back Facebook X (Twitter) WhatsApp LinkedIn Pinterest Copy link Influence of different environmental factors on exercise Last updated: 30/01/25 Published: 10/02/23 The characteristics of environmental factors: - Chemical safety - Air pollution - Climate change and natural disasters - Diseases caused by microbes - Lack of access to health care - Infrastructure issues - Poor water quality - Global environmental issues What are the impacts of these environmental influences on physical activity? An individual may be restricted to a certain range of physical activities which they can participate in. Individuals are usually reliant on the surrounding environment and the maintenance of facilities. If they are not kept well maintained, individuals are usually discouraged. The physiological effect on training: Climate change will disproportionately affect the most vulnerable in our populations, including the very young, the very old, and those with pre-existing health conditions. Training adjustments to compensate for the influence of environmental factors on training: - Treatments for heat stress- stop exercising / move to a shaded or air-conditioned area / remove excess clothing or equipment / drink cold beverages / sit in front of a fan / put a cool piece of cloth around neck / place entire body in cool water e.g. cool bath or shower - Treatments for cold stress- move to a warm environment / remove cold and wet clothes / find access to warm air such as heaters, or fireplace / use electric or non-electric blankets / drink warm beverages Written by Kushwant Nathoo Related articles: Impacts of negligent exercise on physiology / Physical and mental health / Environmental impact of EVs

Conservation, diseases, animal behaviour, adaptation and survival. Expand your knowledge on the incredible diversity of life on Earth with these articles. Zoology Articles Conservation, diseases, animal behaviour, adaptation and survival. Expand your knowledge on the incredible diversity of life on Earth with these articles. You may also like: Biology , and Ecology Deception by African birds The species Dicrurus adsimilis uses deception by flexible alarm mimicry to target and carry out food-theft attempts An experiment on ochre stars Investigating the relative fitness of the species Pisaster ocharceus Orcinus orca A species report Rare zoonotic diseases We all know about COVID-19. But what about the other zoonotic diseases? Article #1 in a series on Rare diseases. Marine iguanas Their conservation The cost of coats 55 years of vicuna conservation in South America. Article #1 in a series on animal conservation around the world. Conserving the California condor These birds live on the west coast of North America. Article #2 in a series on animal conservation around the world. Emperor penguins Kings of ice. Article #6 in a series on animal conservation around the world.

Elements, compounds, and mixtures make up the building blocks of materials that shape our world. Read on to uncover how atoms, molecules, and reactions are fundamental to life on Earth. Chemistry Articles Elements, compounds, and mixtures make up the building blocks of materials that shape our world. Read on to uncover how atoms, molecules, and reactions are fundamental to life on Earth. You may also like: Medicine , Pharmacology The role of chemistry in medicine Medicinal chemistry and its uses Metal organic frameworks And their potential use in cancer drug delivery The biochemistry of cancer And how integrins can be desirable targets Metal compounds In anti-cancer drugs Female Nobel prize winners What were their contributions? Drug chirality Why is it important? Green chemistry And sustainability for the future Chemistry in space exploration What is its role? Environmental impact of electrical vehicles A chemical perspective From botulism to beauty Botulinum toxins Chemistry of an atomic bomb What is the key process behind these explosions? Vitamins Discussing their importance in the body The story of pigments and dyes The chemistry in an artist's palette Zinc fingers Transcription factors regulating gene expression Emotional chemistry On a molecular basis Nuclear safety The silent protectors Modern-day chemistry And its related challenges The story of the atom The history of the atomic model Nanoparticles A probable treatment for diabetes Exploring food at the molecular level Gastronomy Next

Dive into the latest biological research! Explore the profound impact of negligent exercise on well-being, discover breakthroughs in organoid and iPSC research, and gain insights into how biomarkers are enabling disease diagnosis and prevention. Biology Articles Dive into the latest biological research! Explore the profound impact of negligent exercise on well-being, discover breakthroughs in organoid and iPSC research, and gain insights into how biomarkers are enabling disease diagnosis and prevention. You may also like: Cancer , Ecology , Genetics , Immunology , Neuroscience , Zoology , and Medicine Can a human brain be uploaded to a computer? Uncovering the possibilities of transferring information from your brain to a computer Impacts of negligent exercise on physiology How to avoid negligent personal training as it can harm the individual Key historical events in public health A timeline of discoveries in the history of public health Influence of different environmental factors on exercise How different environmental factors can affect exercise Why bacteria are essential to human survival The benefits of bacteria Will diabetes mellitus become an epidemic? Diabetes mellitus is when the body is unable to produce enough insulin or becomes resistant to it Correlation between a country's HDI and COVID-19 mortality rate HDI stands for Human Development Index, i.e. how much a country is developed considering various factors such as wealth Rising food prices Food deserts and malnutrition Organoids in drug discovery What organoids are, their applications in drug discovery and more The genesis of life What came first: the chicken or the egg? Challenges in endometriosis Form underreporting to under-research iPSCs and organoids iPSC stands for induced pluripotent stem cells PCOS and endometriosis These two diseases are very similar, but how are they different? Neutrophil gelatinase-associated lipocalin (NGAL) A biomarker for renal damage Childhood stunting Its issue in developing countries Innovations in the biosciences The biggest ones currently Various health models Understanding health through different stances Medicinal Manuka The benefits of using Manuka honey as medicine The dual role of mitochondria A mechanism for survival, or death? Next

Looking at modern society in terms of the food being consumed and the amount of exercise undertaken collectively, it is entirely inevitable that diabetes will become an epidemic. Now before delving into the above statement further, diabetes mellitus (from Greek ‘siphon’ and Latin ‘sweet’) is a non-communicable disease that occurs when blood sugar levels in the body are so high, that the pancreas is unable to produce adequate insulin in order to manage this problem. Go back Facebook X (Twitter) WhatsApp LinkedIn Pinterest Copy link Will diabetes mellitus become an epidemic? Last updated: 07/11/24 Published: 18/05/23 Defining diabetes and its causes Looking at modern society in terms of the food being consumed and the amount of exercise undertaken collectively, it is entirely inevitable that diabetes will become an epidemic. Now before delving into the above statement further, diabetes mellitus (from Greek ‘siphon’ and Latin ‘sweet’) is a non-communicable disease that occurs when blood sugar levels in the body are so high, that the pancreas is unable to produce adequate insulin in order to manage this problem. Also, diabetes can be categorised into various types, but the most common are types 1 and 2 as well as gestational (which happens during pregnancy). There is also diabetes insipidus (from Latin ‘lacking taste’), and this is where the kidneys are unable to conserve water. The causes of diabetes mellitus can be divided based on the type. Since type 1 can be caused by the body’s immune system attacking the pancreas, this means that the beta cells are unable to make enough insulin because they are damaged. Not only can type 1 diabetes arise this way, it is possible that environmental factors such as diet and viral infections lead to the disease. As for type 2, it primarily comes from insulin resistance, meaning that the body does not respond to the hormone effectively compared to a person without diabetes. This in turn impacts insulin mediated glycogen synthesis and glycolysis leading to hyperglycemia as seen in figure 1. There are many reasons why diabetes is likely to become an epidemic. Firstly, there is a clear connection between obesity and type 2 diabetes which cannot be ignored; this is because an article found that people with both conditions are exacerbated perhaps due to increased non esterified fatty acids (NEFAs) and glycerol among other linked biochemicals. On the other hand, this same article stated that people with type 1 diabetes are not usually obese. Nevertheless, it is vital that in order to prevent the incidence of type 2 diabetes in later life, it is important to implement strategies such as regular exercise and lowering carbohydrate intake in the diet. Alluding to the previous paragraph, one of the major factors to the increase in obesity and type 2 diabetes diagnoses is the sedentary lifestyle or decreased mobility through sitting. A meta-analysis evaluated 10 studies with over 500,000 volunteers and concluded that there was a 112% cumulative increase in type 2 diabetes risk linked to watching TV. Additionally, a study showed that more sedentary time had raised body and trunk fat percentage while there was reduced appendicular skeletal muscle mass. Taking into account these findings among others, it is evident that exercise does play a role in reducing the risk of type 2 diabetes. Counteracting the previous paragraphs, it is equally plausible that diabetes will not be epidemic because there are current pharmaceutical drugs taken orally like sulfonylureas and meglitinides that cause the pancreas to release insulin aside from injection based ones such as amylin mimetics, which maintains blood glucose concentration, which are used for type 2 diabetes. As for those afflicted with type 1 diabetes, they mainly take insulin because they are in deficit of the hormone or they can have a pancreatic transplant, which has more than 96% and 83% survival rates after 1 and 5 years of the operations respectively, although it does have a major complication of rejection like any other type of operation. With regards to future treatments, a review discussed how newer drugs for decreasing blood glucose such as dipeptidyl peptidase-4 (DPP-4) inhibitors have been re-evaluated for cardiovascular outcome trials by showing patients experiencing a decrease in other non-communicable diseases like myocardial infarction and albuminuria, indicating that they can be useful for heart and kidney diseases associated with type 2 diabetes. Furthermore, there are other potential therapies such as probiotics and prebiotics that can be used along with faecal transplants to change the gut microbiome for type 2 diabetes patients. It is uncertain that diabetes will/won’t become an epidemic From a more neutral perspective, there is not enough certainty that diabetes will or will not become an epidemic simply because accurately predicting the future 100% of the time is impossible. As such, the future interventions for treating diabetes may not actually get to exist, perhaps due to prospective factors like politics and societal values with respect to science as well as taking into account the difficulty for a therapeutic method to be put onto the market for the patients to consider. Another point to address is the fact that the human body is so incredibly complex that it took humans thousands of years to truly discover all of the current facts known in relation to its anatomy and physiology along with having some level of understanding of them. Not only that, there are still observations about the human body that are still unclear to scientists today and so the drugs for treating diabetes may or may not be effective depending on who is receiving the therapy because each person is genetically unique. Conclusion Referring to all of the arguments made, it is evident that diabetes is a huge burden for modern and future societies because of its links to obesity or sedentary lifestyle and consuming foods high in carbohydrates. Yet, this issue may be prevented by exploring future therapies, exploiting current ones and implementing non-clinical interventions such as increased regular exercise and reducing carbohydrate intake. Therefore, it is the responsibility of each patient and health organisation to manage diabetes before it becomes even worse. Written by Sam Jarada Related articles: Pre-diabetes / Diabetes drug to treat Parkinson's / The world vs the next pandemic REFERENCES Diabetes UK. Types of diabetes. Diabetes UK. 2022. Paschou SA, Papadopoulou-Marketou N, Chrousos GP, Kanaka-Gantenbein C. On type 1 diabetes mellitus pathogenesis. Endocrine Connections. 2018 Jan;7(1):R38–46. Cersosimo E, Triplitt C, Solis-Herrera C, Mandarino LJ, DeFronzo RA. Pathogenesis of Type 2 Diabetes Mellitus. Nih.gov. MDText.com, Inc.; 2018. Algoblan A, Alalfi M, Khan M. Mechanism linking diabetes mellitus and obesity. Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy. 2014 Dec;7(587–591):587. Barnes AS. The epidemic of obesity and diabetes: trends and treatments. Texas Heart Institute journal. 2011;38(2):142–4. Hamilton MT, Hamilton DG, Zderic TW. Sedentary Behavior as a Mediator of Type 2 Diabetes. Medicine and Sport Science. 2014;60:11–26. Li D, Yang Y, Gao Z, Zhao L, Yang X, Xu F, et al. Sedentary lifestyle and body composition in type 2 diabetes. Diabetology & Metabolic Syndrome. 2022 Jan 15;14(1). Mayo Clinic. Diabetes treatment: Medications for type 2 diabetes. Mayo Clinic. 2018. Bahar SG, Devulapally P. Pancreas Transplantation. PubMed. Treasure Island (FL): StatPearls Publishing; 2022. Bailey CJ, Day C. The future of new drugs for diabetes management. Diabetes Research and Clinical Practice. 2019 Sep;155:107785. Bailey CJ, Day C. Treatment of type 2 diabetes: future approaches. British Medical Bulletin. 2018 Jun 1;126(1):123–37.