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And a hope for a more sustainable future Facebook X (Twitter) WhatsApp LinkedIn Pinterest Copy link Green Chemistry 05/02/25, 16:33 Last updated: Published: 29/06/23, 10:33 And a hope for a more sustainable future Green Chemistry is a branch of chemistry that takes into consideration the design of synthetic reactions to minimise the generation of hazardous by-products, their impact on humans and the environment. Often reactions are designed to take place at low temperatures with short reaction times and increased yields. This is preferred as fewer materials are used and it is more energy efficient. When designing routes it is important to consider ‘How green is the process?’ in this way we are shifting focus to a more sustainable future where we are emitting fewer pollutants, using renewable feedstocks and energy sources with minimal waste. In 1998 Paul Anastas and John Warner devised the twelve principles of Green Chemistry. They serve as a framework for scientists to design innovative scientific solutions to existing and new synthetic routes. Scientists are looking into environmentally friendly reaction schemes which can simplify production as well as being able to use greener resources. It is impossible to fulfil all twelve principles at the same time but making attempts to apply as many principles as possible when designing a protocol is just as good. The twelve principles are: Prevention: waste should be prevented rather than treating waste after it has been created. Atom Economy: designing processes where you are maximising the incorporation of all materials so all reagents are in the final product. Less Hazardous Chemical Synthesis : synthetic methods should be designed to be safe and the hazards of all the substances should be reviewed. Designing Safer Chemicals: designed to eliminate chemicals which are carcinogenic, neurotoxic, etc. essentially safe to the Earth. Safer Solvents and Auxiliaries: using auxiliary substances and minimising usage of solvents to reduce waste created. Design for Energy Efficiency: designing synthetic methods where reactions can be conducted at ambient temperature and pressure. Use of Renewable Feedstock: raw materials used for reactions should be renewable rather than depleting. Reduce Derivatives: reducing the steps required in a reaction by using catalysts/ enzymes and adding protecting or deprotecting groups or temporary modification of functionality. Extra steps require more reagents and generate a lot of waste. Catalysis: catalysts lower energy consumption and increase reaction rates. They allow for decreased use of harmful and toxic chemicals. Design for Degradation: chemical products should be designed so that they can break down and have no harmful effects on the environment. Real-time analysis for Pollution Prevention: analytical techniques required to allow monitoring of the formation of hazardous substances. Inherently Safer Chemistry for Accident Prevention: involves using safer chemical alternatives to prevent the occurrence of an accident e.g. fires; explosions. Some examples of areas where Green Chemistry is implemented: Computer Chips: the use of supercritical carbon dioxide as a step for the preparation of a chip. This has reduced the quantities of chemicals, water and energy required to produce chips. Medicine: developing more efficient ways of synthesising pharmaceuticals e.g. chemotherapy drug Taxol. Green Chemistry is widely being implemented in academic labs as a way to reduce the environmental impact and high costs. As of today and the future mainstream chemical industries have not fully embraced green chemistry and engineering with over 98% of organic chemicals being derived from petroleum. This branch in Chemistry is still fairly new and will likely be one of the most important fields in the future. Written by Khushleen Kaur Related article: The challenges in modern day chemistry Project Gallery

Second most common anaemia Facebook X (Twitter) WhatsApp LinkedIn Pinterest Copy link Anaemia of chronic disease 09/07/25, 10:49 Last updated: Published: 24/08/23, 16:06 Second most common anaemia This article is no. 3 of the anaemia series. Next article: sideroblastic anaemia . Previous article: Iron-deficiency anaemia. Pathogenesis The second most prevalent anaemia is anaemia of chronic disease (ACD), it is more often seen alongside chronic infections or malignancies, other causes include infections, autoimmune diseases, and transplant rejection. The pathogenesis of the condition is greatly lead by the effectiveness of the immune system, the immune response to tumour cells and pathogens is to remove and deny access to iron, which is needed to thrive. The processes are mainly thought to be mediated through cytokines such as TNF, IL-6s and IFN as well as the acute phase protein hepcidin. IL-6 is a very powerful cytokine in that it can inhibit erythropoiesis through the downregulation of gene expression; SLC4a1 reducing haemoglobin production, it increases ferratin production whilst inhibiting TNF-α, it upregulates DMT-1 which is a protein (transmembrane) involved in iron uptake in macrophages and it upregulates the production of hepcidin. Hepicidin Hepcidin is a peptide hormone, 25 amino acid chain protein, derived mainly from hepatic cells its synthesis is induced as a response to iron overload or inflammation, its presence crucial in the diagnosis of ACD. IL-6 induces hepcidin release from hepatocytes, upregulation causes the transport protein (ferroportin) degradation inhibiting iron absorption in duodenum enterocytes and macrophage recycling via upregulation of dMT-1 and mobilization of stored iron resulting in low iron plasma. Clinical presentation A patient with ACD may have low haemoglobin (Hb) and the reticulocyte index (new RBC) count may be reduced also, this is a common feature of an iron deficient anaemia. A blood film may help diagnose the underlying condition, but the red cell morphology varies greatly, less than half can be microcytic or hypochromic. Iron studies are what helps ACD stand out from the other anaemias, raised IL-6, hepcidin and ferratin are the key markers; the presence of iron results with raised ferratin and iron will be seen if a blood film is stained correctly. There may also be reduced serum iron, % saturation and TIBC. Should erythrocyte sedimentation rates be high Rouleaux’s may be seen, which are aggregations of RBC. Conclusion The most efficient way to diagnose an anaemia is through serum biomarkers in a FBC and iron studies. Hepcidin and other chemical markers play a key role in the diagnosis of ACD. Iron studies help to paint a clearer picture when diagnosing anaemias but should be supported with a medical history alongside a clinical examination, as comorbidities may influence chronic inflammatory markers. Written by Lauren Kelly Project Gallery

The science behind tooth decay Facebook X (Twitter) WhatsApp LinkedIn Pinterest Copy link How to prevent tooth decay 10/04/25, 10:52 Last updated: Published: 03/02/24, 11:24 The science behind tooth decay Dental caries, commonly referred to as tooth decay, manifests as a gradual process and progressive disease affecting the dental hard tissues, resulting in the breakdown of tooth structure and the potential for pain and infection within the oral cavity. Understanding the mechanisms behind tooth decay is crucial for adopting effective preventative measures, to stop or reverse the carious process and prevent cavity formation. Several factors contribute to dental caries, including bacteria, time, fermentable carbohydrates, and a susceptible tooth surface. In the absence of regular toothbrushing, a plaque biofilm is allowed to form on the tooth surface—a sticky, colourless film that serves as a breeding ground for bacteria such as Streptococcus mutans and Lactobacillus species. Once these bacterial species encounter fermentable carbohydrates and sugars from our diet, they begin to metabolise them, producing acids as a by-product. These acids contribute to an acidic environment in the mouth. When enamel, the outermost layer of tooth structure, is exposed to an acidic pH below 5.5, its mineral structure weakens, initiating the dissociation of hydroxyapatite crystals. Frequent acid attacks from dietary sugars result in a net mineral loss in teeth, leading to cavity formation, dental pain, and potential infections. The initial stage of decay involves the demineralisation of enamel. At this point, the damage can be reversible with good oral hygiene practices and through remineralising agents. Saliva has the capacity to remineralise initial carious lesions, and fluoride application through fluoridated toothpaste can also aid in reversing the initial stages of dental caries. However, if left untreated and allowed to progress, the decay can develop further into the tooth structure reaching the softer dentine beneath enamel. Dentin decay occurs more rapidly than enamel and can contribute to increased sensitivity and discomfort. As the decay advances, it may reach the dental pulp, which is the nerve of the tooth. Infection of the pulp can trigger severe pain and may necessitate root canal treatment in attempt to save the tooth. Persistent infections can lead to abscess formation—a pocket of pus causing swelling, pain, and systemic health issues, should the infection spread throughout the body. Tooth decay can be preventing through regular brushing with a fluoride toothpaste. The consistent disturbance to the plaque biofilm formation through brushing it away will not allow the caries process to continue, and hence prevent cavity formation. The fluoride aspect will help to strengthen the enamel and remineralise any mineral loss found in early lesions; this can stop and even reverse the carious process, thus preventing dental decay A healthy diet with limited consumption of sugary foods and drinks can significantly reduce the risk of tooth decay; with less sugars in the oral environment there is a lower rate of bacterial metabolisation to create the acids which contribute to the decay process. Regular dental check up appointments enable early detection and intervention of any initial lesions, preventing the progression of decay before reaching an irreversible status. Tooth decay is a preventable yet prevalent oral health issue. Instigated by the action of oral bacteria metabolising sugars in the mouth, our natural tooth structure can be destructed and decayed if the plaque biofilm is not controlled. By understanding the causes and progression of tooth decay, individuals can adopt proactive measures to maintain good oral hygiene, preserve enamel, and safeguard their smiles for a lifetime. Regular dental check-ups and a commitment to a healthy lifestyle play pivotal roles in preventing the onset and progression of tooth decay. Written by Isha Parmar Related article: Importance of calcium REFERENCE (Banerjee & Watson, 2015): Banerjee, A. and Watson, T.F. (2015) Pickard’s Guide to Minimally Invasive Operative Dentistry, King’s College London. Project Gallery

Unlocking the potential to tackle plastic pollution in oceans Facebook X (Twitter) WhatsApp LinkedIn Pinterest Copy link Genetically-engineered bacteria break down plastic in saltwater 09/07/25, 14:14 Last updated: Published: 29/09/23, 20:19 Unlocking the potential to tackle plastic pollution in oceans Groundbreaking discovery in the fight against plastic pollution North Carolina State University researchers have made a groundbreaking discovery in the fight against plastic pollution in marine environments. They have successfully genetically engineered a marine microorganism capable of breaking down polyethylene terephthalate (PET), a commonly used plastic found in water bottles and clothing, contributing to the growing problem of ocean microplastic pollution. Introducing foreign enzymes to V. natriegens The modified organism, created by incorporating genes from the bacterium Ideonella sakaiensis into the genome of Vibrio natriegens , can effectively degrade PET in saltwater conditions. This achievement marks the first time foreign enzymes have been successfully expressed on the surface of V. natriegens cells, making it a significant scientific breakthrough. PET microplastics pose a significant challenge in marine ecosystems, and current methods of removing them, such as extracting and disposing of them in landfills, are not sustainable. The researchers behind this study aim to find a more environmentally friendly solution by breaking down PET into reusable products, like thermoformed packaging (takeaway cartons) or textiles (clothing, duvets, pillows, carpeting). The team worked with two bacteria species, V. natriegens and I. sakaiensis . V. natriegens , known for its rapid reproduction in saltwater, served as the host organism, while I. sakaiensis provided the enzymes necessary for PET degradation. The researchers first rinsed the plastics collected from the ocean to remove high-concentration salts before initiating the plastic degradation process. Challenges ahead While this breakthrough is a significant step forward, three key challenges are still ahead. The researchers aim to incorporate the DNA responsible for enzyme production directly into the genome of V. natriegens to enhance stability. Because DNA is the genetic material responsible for the production of enzymes, and enzymes are proteins that are responsible for carrying out various chemical reactions in the body, by incorporating the DNA responsible for enzyme production into the genome of V. natriegens , the researchers can enhance the stability of the enzyme production. Thus, this DNA is essential for producing the enzymes necessary for PET degradation, as it contains the genetic information vital for encoding the proteins needed for PET breakdown. Additionally, the research team plans to modify V. natriegens further to feed on the byproducts generated during PET degradation. Lastly, they seek to engineer V. natriegens to produce a desirable end product from PET, such as a molecule that can be utilised in the chemical industry. Collaboration with industry groups Collaboration with industry groups is also crucial in determining the market demand for the molecules that V. natriegens can produce. The researchers are open to working with industry partners to explore the vast production scale and identify the most desirable molecules for commercial use. By introducing the genes responsible for PET degradation into V. natriegens using a plasmid, the researchers successfully induced the production of enzymes on the surface of the bacterial cells. The modified V. natriegens demonstrated its ability to break down PET microplastics in saltwater, providing a practical and economically feasible solution for addressing plastic pollution in marine environments. This research represents a significant advancement in the field, as it is the first time that V. natriegens has been genetically engineered to express foreign enzymes on its cell surface. This breakthrough opens up possibilities for further modifications, such as incorporating the DNA from I. sakaiensis directly into the genome of V. natriegens to make the production of plastic-degrading enzymes a more stable feature of the organism. The researchers aim to modify V. natriegens to feed on the byproducts produced during the breakdown of PET and create a desirable end product for the chemical industry. The researchers are open to collaborating with industry groups to identify the most desirable molecules to be engineered into V. natriegens for production. This groundbreaking research, published in the AIChE Journal with the support of the National Science Foundation under grant 2029327, paves the way for developing more efficient and sustainable methods for addressing plastic pollution in saltwater environments. Conclusion The research has made a breakthrough in the fight against plastic pollution in marine environments. By incorporating genes from the bacterium I. sakaiensis into the genome of V. natriegens , they created a genetically modified marine microorganism capable of breaking down PET. This achievement provides a practical and economically feasible solution to address plastic pollution in aquatic ecosystems. The researchers are now looking into further modifications to the organism to enable it to feed on byproducts and to produce a desirable end product that can be used in the chemical industry. This research highlights the potential of genetic engineering to create sustainable solutions to the growing problem of plastic pollution. Written by Sara Maria Majernikova Related article: Plastics and their environmental impact Project Gallery

A new theory suggests intelligence develops through reciprocal interactions between abilities Facebook X (Twitter) WhatsApp LinkedIn Pinterest Copy link A primer on the Mutualism theory of general intelligence 11/12/25, 14:15 Last updated: Published: 10/10/24, 14:19 A new theory suggests intelligence develops through reciprocal interactions between abilities Introduction One of the most replicated findings in psychology is that if a sufficiently large and diverse battery of cognitive tests is administered to a representative sample of people, an all-positive correlation matrix will be produced. For a century, psychometricians have explained this occurrence by proposing the existence of g, a latent biological variable that links all abilities. G is statistically represented by the first factor derived from a correlation matrix using a method called factor analysis, which reduces the dimensionality of data into clusters of covariance between tests called factors. Early critics of g pointed out that nothing about the statistical g-factor required the existence of a real biological factor and that the overlap of uncorrelated mental processes sampled by subtests was sufficient. While the strength of correlations between subtests does generally correspond to intuitive beliefs about processes shared between them, this is not universally the case, and for this reason, sampling theory has never seen widespread acceptance. A new theory called mutualism has been proposed that explains the positive manifold without positing the existence of g. In mutualism the growth of abilities is coupled, meaning improvement in one domain causes growth in another, inducing correlations between abilities over time. The authors of the introductory paper demonstrated in a simulation that when growth in abilities is coupled the interaction between baseline ability, growth speed and limited developmental resources is sufficient to create a statistical general factor from abilities that are initially uncorrelated, offering a novel explanation for why abilities like vocabulary that are ‘inexpensive’ in terms of developmental resources explain the most variance in other abilities. Empirical evidence In the field of intelligence, mutualism has been tested twice among neurotypical children in the lab and once in a naturalistic setting with data from a gamified maths revision platform. Alongside these, a lone study exists comparing coupling in children with a language disorder and neurotypical children, however methodological issues related to attrition preclude it from discussion here. All studies used latent change score modelling (LCSM) to compare competing models of how intelligence develops over time. LCSM is a subset of structural equation modelling in which researchers compare the discrepancy between models of proposed causal connections between variables and their values in the real data using model fit indices. Three parameters resembling those used in the introductory paper’s simulations were used to represent causal connections between variables: the change score - wave #2 score minus wave #1 score of the same ability, the self-feedback parameter – the regression coefficient of baseline ability on the change score of the same ability and the coupling effect parameter – the regression coefficient of one ability at wave #1 on the change score of the other ability. The following models were compared: the g-factor model defined by the absence of coupling and growth driven by change in the g-factor, the investment model defined by coupling from matrix reasoning to vocabulary and the mutualism model defined by bidirectional coupling. Mutualism in the lab The first two lab studies investigated coupling between vocabulary and matrix reasoning in samples of 14-25 year olds and 6-8 year olds respectively. The mutualism model showed the best model fit in both studies albeit less decisively in the three wave younger sample, suggesting the stronger model fit of the first study may have been an artefact of regression to the mean. I think it’s problematic to interpret this as empirical support for mutualism due to issues that follow from only using two abilities. A g-factor extracted from two abilities may reflect specific non-g variance shared between tests as much as it does common variance caused by g. Adding to this ambiguity is the fact that the correlations between the change scores of the two tests after controlling for coupling and self-feedback effects were positive, reflecting the influence of an unmodelled third variable, be that g or unmeasured coupling. Another problematic feature of the studies comes from their model specification of the g-factor as being without coupling. This is despite the fact no latent change score modelling study of childhood development has ruled out that g may develop in a coupled or partially coupled manner. Studies using the methodology to study cognitive ageing have shown that some abilities are coupled whereas others are not suggesting that only sampling abilities that do show coupling may lead to a biassed comparison. Mutualism in the classroom Mutualism showed a marginally better fit than the investment model in explaining the development of counting, addition, multiplication and division over three years in a study featuring a sample of 12,000 Dutch 6-10 year olds using the revision platform Mathgarden. The change scores of each ability showed strong correlations after controlling for coupling and self-feedback effects. When considered in relation to the good model fit of the investment model, I believe this may reflect the standardised effect of the curriculum on the development of abilities independent of coupling and baseline ability. A finding with negative implications for mutualism from this study is the fact that the number of games played was not associated with any greater strength in coupling. This could reflect that coupling is a passive mechanism of development with little environmental input but it could equally reflect sorting of high ability students into a niche combined with self-feedback effects of their baseline ability impeding coupling. To observe the causal effect of effort on coupling after controlling for cognitive aging and the tendency of high ability people to train harder a randomised control trial of cognitive training is needed. Cognitive training Unfortunately, no cognitive training study has used latent change score modelling, meaning coupling must be inferred from the presence of far transfer (gains on untrained abilities), rather than directly estimated. COGITO’s youth sample resembled the first lab study to test mutualism in its age range and choice of fluid reasoning as a far transfer measure. Participants underwent 100 days of hour-long training sessions of working memory, processing speed and episodic memory. The authors found no near or far transfer gains for working memory and processing speed, possibly indicating developmental limits on their improvement. However, moderate effect sizes were found for fluid reasoning and episodic memory. The study’s results are lacklustre and developmentally bound but they offer an example of experimentally induced far transfer in a literature – in which it is a rarity – leaving open the possibility that the coupling effects observed in the lab studies were not mere passive effects of development. In contrast to COGITO which targeted young people at the tail end of their cognitive development, the Abecedarian Project started almost as soon as the subjects were born. Conceived of as a pre-school intervention to improve the educational outcomes of African Americans in North Carolina, the Abecedarian Project consisted of an experimental group that received regular guided educational play for infants aimed at building early language and a control condition which only received nutritional supplementation. At the entry of primary school, the experimental group showed a 7 point difference in IQ, which persisted in a diminished capacity at 4.4 IQ points by age 21. In contrast to previous early life interventions, in cognitive training studies and studies on the cognitive outcomes of adoption the gains were domain general rather than improvements on specific abilities. This provides causal evidence that if interventions are sufficiently early and target highly g-loaded abilities such as vocabulary they can induce cascades of domain-general improvement, a finding in line with the predictions of mutualism. It would be unfair to end this segment without mentioning perhaps the most standardised cognitive training regime there is: schooling. The causal effect of a year of schooling on IQ can be teased apart from the developmental effects of ageing by using a method called regression discontinuity analysis. In this method, the distance of a student’s birthday from the year cutoff for two year groups is used as a predictor variable alongside the school year in a multiple regression predicting IQ. A recent paper reanalysing data from a study using this method found that the subtest gains from a year of schooling showed a moderate negative correlation with their g loading. As mutualism states that g develops through coupling, this would lend credence to the view that coupling effects are passive mechanisms of g’s development rather than being inseparable from experience. Conclusion I believe that it’s more accurate to say there is evidence for coupling effects than it is to say there is evidence for mutualism. There is convergent evidence from a year of schooling effect, coupling effects not rising with the amount of maths games played and the COGITO intervention’s results that the environment has little causal role in coupling effects and their strength. Opposing evidence comes from the Abecedarian Project, however this is not an environmental stimulus to which most people will be exposed to. Therefore, more weight should be placed on the effects of a year of schooling because it is generalisable. To reconcile this conflicting evidence, future authors should seek to replicate the COGITO intervention in an early adolescent identical twin sample with co-twin controls. This would allow researchers to observe coupling effects while executive functions are still in development and give them a more concrete understanding of the self-feedback parameter grounded in developmental cascades of gene expression. A more readily available alternative would be to apply latent change score modelling to the Abecedarian Project dataset. I will end with a quote from a critic of mutualism, Gilles Gignac: I conclude with the suggestion that belief in the plausibility of the g factor (or mutualism) may be impacted significantly by individual differences in personality, attitudes, and worldviews, rather than rely strictly upon logical and/or empirical evidence. As the current evidence stands, this may be true, but with the availability of new developmental studies such as the Adolescent Brain Cognitive Development study and old ones like the Louisville twin study there’s less of an excuse than ever. Written by James Howarth Related articles: Nature vs nurture in childhood intelligence / Does being bilingual make you smarter? REFERENCES Carroll, J. B. (1993). Human cognitive abilities: A Survey of Factor-Analytic Studies . Cambridge University Press Rindermann, H., Becker, D., & Coyle, T. R. (2020). Survey of expert opinion on intelligence: Intelligence research, experts’ background, controversial issues, and the media. Intelligence , 78 , 101406. https://doi.org/10.1016/j.intell.2019.101406 Spearman, C. (1904). “General intelligence,” objectively determined and measured. The American Journal of Psychology , 15 (2), 201. https://doi.org/10.2307/1412107 Thomson, G. H. (1916). A hierarchy without a general factor. British Journal of Psychology 1904-1920 , 8 (3), 271–281. https://doi.org/10.1111/j.2044-8295.1916.tb00133.x Jensen, A. R. (1998). The g factor: The science of mental ability. Praeger Publishers/Greenwood Publishing Group Van Der Maas, H. L. J., Dolan, C. V., Grasman, R. P. P. P., Wicherts, J. M., Huizenga, H. M., & Raijmakers, M. E. J. (2006). A dynamical model of general intelligence: The positive manifold of intelligence by mutualism. Psychological Review, 113 (4), 842–861. https://doi.org/10.1037/0033-295X.113.4.842 Johnson, W., Nijenhuis, J. T., & Bouchard, T. J. (2008). Still just 1 g: Consistent results from five test batteries. Intelligence , 36 (1), 81–95. https://doi.org/10.1016/j.intell.2007.06.001 Project Gallery

The slippery property of a superfluid is caused by its ability to flow very easily Facebook X (Twitter) WhatsApp LinkedIn Pinterest Copy link The incredibly slippery nature of superfluids 03/04/25, 10:33 Last updated: Published: 24/05/23, 08:53 The slippery property of a superfluid is caused by its ability to flow very easily Slipperiness is a property that we often associate with everyday objects like ice, soap, and banana peels. However, there is a substance that is even more slippery than these: superfluids. A normal liquid becomes a superfluid when it is cooled down below a certain temperature. This temperature is unique to all fluids, for example for helium it is 2.17 K. Below this temperature, the superfluid will behave in completely unique ways. For example, if a container of water at room temperature was spun, you’d expect the water to also spin around, creating a whirlpool. Whereas a superfluid in a spinning container doesn’t spin at all, until it reaches a certain speed! The slippery property of a superfluid is caused by its ability to flow very easily. Usually it’s safe to leave a glass of water on a countertop (unless of course you’ve got a particularly excitable dog), but if you were to leave a glass of superfluid on a table, the liquid would creep out and escape. The tiny changes in temperature or pressure in the container cause it to flow, seemingly defying gravity. Unfortunately, superfluids cannot just be bought in the local supermarket! To produce a superfluid, devices known as cryostats can be used to cool a substance down to low temperatures. Using the ideal gas model, pressure, and volume can be related, so by reducing the pressure, the temperature of the device can also be decreased. The pressure is reduced using a vacuum pump, which works by removing particles from the cryostat. The applications of superfluids are limited as, due to the typically very low temperatures needed for a normal fluid to transition to a superfluid, there is difficulty in producing superfluids. Currently, scientists are working on finding fluids that enter a stable superfluid state at room temperatures. However, superfluids are used within many fields of physics to explain certain phenomena. One theory is that the core of collapsed large stars (neutron stars) is a superfluid, despite the very hot temperatures. The idea is that below a certain temperature, it uses less energy for the core to behave like a superfluid which cools the star down at an increased rate. The superfluid theory of neutron stars is just a hypothesis, however hints at the role superfluids play in all areas of physics. Written by Madeleine Hales REFERENCES/ FURTHER READING: https://www.aps.org/publications/apsnews/200601/history.cfm#:~:text=In%201927%20Willem%20Keesom%20and,helium%20I%20and%20helium%20II . https://physicsworld.com/a/neutron-star-has-superfluid-core/ Project Gallery

Landing on the moon (again!) Facebook X (Twitter) WhatsApp LinkedIn Pinterest Copy link Artemis: the Lunar South Pole Base 09/07/25, 10:55 Last updated: Published: 13/01/24, 15:44 Landing on the moon (again!) Humans have not visited the moon since 1972, but that’s about to change. Thanks to NASA’s Artemis missions, we have already taken the first small step towards our own lunar home for astronauts. NASA has established the second generation of its lunar missions- “Artemis”, fittingly named after the ancient Greek Goddess of the Moon, and Apollo’s twin. The ultimate aim of the Artemis missions is to solidify a stepping stone to Mars. Technologies will be developed, tested, and perfected, before confidence is built to travel on to Mars. NASA has to consider the natural conditions of the Moon, since doing so will allow astronauts to limit their reliance on resources from Earth, and increase their length of stay and therefore potential for research. The amount achieved would be extremely limited if a lunar mission relied solely on resources from Earth, due to the limitation of rocket payloads. This is known as In-Situ Resource Utilisation, and in addition to extended lunar stays, its success on the Moon is essential if we hope to one day establish a base on Mars. As a priority, astronauts need to have access to energy and water. Luckily, the conditions at the lunar south pole may be ideal for this. Unlike Earth, where we experience seasons due to its 23.5° tilt, the Moon’s tilt is tiny, at only 1.5°. This means some areas at the lunar poles are almost always exposed to sunlight, providing a reliable source of solar energy generation for a potential Artemis Base Camp. And since the Sun is always near the horizon at the poles, there are even areas in deep craters that never see the light. These areas of “eternal darkness” can reach temperatures of -235°, possibly allowing astronauts access to water ice. Aside from access to resources, Artemis has to consider the dangers that come from living in space. Away from the safety of Earth’s protective atmosphere and magnetosphere, astronauts would be exposed to harsh solar winds and cosmic rays. To combat this, NASA hopes to make use of the terrain surrounding the base, highlighting another advantage of the hilly south pole [3]. The exact location for the Artemis Base is currently undecided. We just know it will most likely be near a crater rim by the south pole, and on the Earth-facing side to allow for communication to and from Earth. Not only is the south pole ideal from a practical standpoint, it is also an area of exciting scientific interest. Scientists will have access to the South Pole–Aitken basin, not only the oldest and largest confirmed impact crater on the Moon, but the second largest confirmed impact crater in the entire Solar System. With a depth of up to 8.2 km, and diameter of 2500 km, it is thought this huge crater will contain exposed areas of lower crust and mantle, providing an insight into the Moon’s history and formation. Additionally, thanks to areas of “eternal darkness” the ice water found deep within craters at the south pole may hold trapped volatiles up to 3.94 billion years old, which, although not as ancient as previously expected, can still provide an insight into the evolution of the Moon. The scientific potential of the Artemis Base Camp extends far beyond location specific investigations to our most fundamental understanding of physics, from Quantum Physics to General Relativity. Not to mention the astronauts themselves, as well as “model organisms” which will be the focus of physiological studies into the effects of extreme space environments. Artemis Timeline Overview Artemis 1 launched on 16th November 2022. It successfully tested the use of two key elements of the Artemis mission- Orion and the Space Launch System (SLS)- with an orbit around the moon. Orion, named after the Goddess Artemis' hunting partner, is the spacecraft that will carry the Artemis crew into lunar orbit. It is carried by the SLS, NASA’s super heavy-lift rocket, one of the most powerful rockets in the world. Artemis 2 plans to launch late 2024 and will be the first crewed Artemis mission, with a lunar flyby bringing four astronauts further than humans have ever travelled beyond Earth. Artemis 3 plans to launch the following year. It will be the historic moment that will see humans step foot on the surface of the moon for the first time since we left in 1972. The mission will be the first use of another key element of the Artemis missions- the Human Landing System (HLS). Astronauts will use a lunar version of SpaceX’s Starship rocket as the HLS for Artemis 3 and 4. (Starship is currently in its test stage, with its second test launch carried out very recently on the 18th November 2023.) Two astronauts will stay on the lunar surface for about a week, beating the current record of 75 hours on the Moon by Apollo 17. Artemis 4 plans to launch in 2028. The mission will include the first use of Gateway, another key element to the Artemis missions. Gateway will be a multifunctional lunar space station, designed to transfer astronauts between Orion and HLS, as well as hosting astronauts to live and research in lunar orbit. Gateway will be constructed over Artemis 4-6 , with each mission completing an additional module. NASA plans to have Artemis missions extending for years beyond this, with over 10 proposed and more expected. Eventually we will have a working base on the Moon with astronauts able to stay for months at a time. Having already started a year ago, Artemis will continue to expand our horizons. We can look forward to uncovering long held secrets of the Moon, and soon, setting our sights confidently on Mars. Written by Imo Bell Related articles: Exploring Mercury / Fuel for the colonisation of Mars / Nuclear fusion REFERENCES How could we live on the Moon? - Institute of Physics. Available at: https://www.iop.org/explore-physics/moon/how-could-we-live-on-the-moon Understanding Physical Sciences on the Moon - NASA. Available at: https://science.nasa.gov/lunar-science/focus-areas/understanding-physical-sciences-on-themoon NASA’s Artemis Base Camp on the moon will need light, water, elevation - NASA. Available at: https://www.nasa.gov/humans-in-space/nasas-artemis-base-camp-on-the-moon-will-need-ligh t-water-elevation Zuber, M.T. et al. (1994) ‘The shape and internal structure of the Moon from the Clementine Mission’, Science, 266(5192), pp. 1839–1843. doi:10.1126/science.266.5192.1839. Flahaut, J. et al. (2020) ‘Regions of interest (ROI) for future exploration missions to the Lunar South Pole’, Planetary and Space Science, 180, p. 104750. doi:10.1016/j.pss.2019.104750. Moriarty, D.P. et al. (2021) ‘The search for lunar mantle rocks exposed on the surface of the Moon’, Nature Communications, 12(1). doi:10.1038/s41467-021-24626-3. Estimates of water ice on the Moon get a ‘dramatic’ downgrade - Physics World. Available at: https://physicsworld.com/a/estimates-of-water-ice-on-the-moon-get-a-dramatic-downgrade Biological Systems in the lunar environment - NASA. Available at: https://science.nasa.gov/lunar-science/focus-areas/biological-systems-in-the-lunar-environme Https://www.nasa.gov/wp-content/uploads/static/artemis/NASA : Artemis - NASA. Available at: https://www.nasa.gov/specials/artemis Project Gallery

An extensive collection of insightful reviews on the best STEM books available. Whether you're a student looking to deepen your knowledge or something to aid your revision and research, an educator seeking great resources for your classroom, or simply a curious mind passionate about science, technology, engineering, mathematics, medicine and more, you'll find something here to inspire and inform you.  Discover Your Next Great Read Deep Dive into STEM Books Here you can explore an extensive collection of insightful reviews on the best STEM books available. Whether you're a student looking to deepen your knowledge or something to aid or complement your revision and research, an educator seeking great resources for your classroom, or simply a curious mind passionate about science, technology, engineering, mathematics, medicine and more, you'll find something here to inspire and inform you. Our Curated Selections: Intern Blues by Robert Marion, M.D. The Emperor of All Maladies by Siddhartha Mukherjee The Molecule by Dr Rick Sax and Marta New

Exploring the microscopic world of molecules Facebook X (Twitter) WhatsApp LinkedIn Pinterest Copy link Quantum Chemistry Last updated: 05/02/26, 10:12 Published: 06/02/25, 08:00 Exploring the microscopic world of molecules Quantum chemistry provides a glimpse into the strange and fascinating world of molecules and atoms, where the principles of traditional chemistry and physics no longer apply. While classical chemistry can explain molecular interactions and bonding, it cannot fully account for particles' unusual, frequently contradictory behaviour at the atomic and subatomic levels. Quantum mechanics provides scientists with a powerful framework for understanding the complicated behaviour of electrons and nuclei in molecules. The basics of quantum chemistry The notion of wave-particle duality, which states that particles, such as electrons, act not just like objects with mass but also like waves, is central to quantum chemistry. Because the exact position and momentum of an electron cannot be known at the same time (according to the Heisenberg Uncertainty Principle), probability distributions are used to describe electrons rather than accurate orbits. These distributions are represented by mathematical functions known as wave functions, which describe the probability of finding an electron in a specific location surrounding the nucleus. This fundamentally affects our understanding of chemical bonding. Instead of conceiving a bond as a solid connection between two atoms, quantum chemistry defines it as the overlap of electron wave functions, which can result in a variety of molecular topologies depending on their energy levels. Quantum mechanics and bonding theories Quantum mechanics has fundamentally altered our knowledge of chemical bonding. The classic Lewis structure model, which explains bonding as the sharing or transfer of electrons, is effective for simple molecules but fails to convey the complexities of real-world interactions. In contrast, quantum chemistry introduces the concept of molecular orbitals. In molecular orbital theory, electrons are not limited to individual atoms but can spread across a molecule in molecular orbitals, which are combinations of atomic orbitals from the participating atoms. These molecular orbitals provide a more detailed explanation for bonding, especially in compounds that do not match simple bonding models, such as delocalised systems like benzene or metals. For example, quantum chemistry explains why oxygen is paramagnetic (it possesses unpaired electrons), a characteristic that classical bonding theories cannot explain. Quantum chemistry and quantum computing One of the most interesting frontiers in quantum chemistry is its application to the development of quantum computers. Traditional computers, despite their enormous processing power, struggle to model the complicated behaviour of molecules, particularly large ones. This is because simulating molecules at the quantum level necessitates tracking all conceivable interactions between electrons and nuclei, which can quickly become computationally challenging. Quantum computers use fundamentally different ideas. They employ qubits, which, unlike classical bits, can exist in a state of both 0 and 1. This enables quantum computers to execute several calculations concurrently and manage the complexity of molecular systems considerably more effectively. This could lead to advancements in quantum chemistry, such as drug discovery, where precisely modelling molecular interactions is critical. Instead of depending on trial and error, scientists may utilise quantum computers to model how possible pharmaceuticals interact with biological molecules at the atomic level, thereby speeding up the creation of novel therapies. Similarly, quantum chemistry could help in the development of novel materials with desirable qualities, such as stronger alloys and more efficient energy storage devices. Why quantum chemistry matters The consequences of quantum chemistry go well beyond the lab. Understanding molecular behaviour at its most fundamental level allows us to create new technologies and materials that have an impact on everyday life. Nanotechnology, for example, relies largely on quantum principles to generate innovative materials with applications in medicine, electronics, and clean energy. Catalysis, the technique of speeding up reactions, also benefits from quantum chemistry insights, making industrial operations more efficient, such as cleaner fuel generation and more effective environmental remediation. Furthermore, quantum chemistry provides insights into biological processes. Enzymes, the proteins that catalyse processes in living organisms, work with a precision that frequently defies standard chemistry. Tunnelling, quantum phenomena in which particles slip past energy barriers, helps to explain these extraordinarily efficient biological processes. In brief, quantum chemistry provides the fundamental understanding required to push the limits of chemistry and physics by exposing how molecules interact and react in ways that traditional theories cannot fully explain. Quantum chemistry has the potential to radically alter our understanding of the microscopic world, whether through theoretical models, practical applications, or future technology advancements. Written by Laura K Related articles: Quantum computing / Topology / Computational organic chemistry Project Gallery

Health in Syria and Lebanon are hindered by inequities and inequalities stemming primarily from warfare Facebook X (Twitter) WhatsApp LinkedIn Pinterest Copy link Syria and Lebanon’s diverging yet connected struggles Last updated: 05/02/26, 10:11 Published: 19/06/25, 07:00 Health in Syria and Lebanon are hindered by inequities and inequalities stemming primarily from warfare This is article no. 4 in a series about global health injustices. Previous article: Yemen- a neglected humanitarian crisis . Next article: Injustices in conflicted Kashmir . Introduction Welcome to the fourth article of the Global Health Injustices Series. The previous article discussed Yemen, specifically how the health and well-being of the population are affected by the intricate geopolitics at play. In this article, I collaborated with Jana Antar , to discuss Syria and Lebanon. Although these countries border one another, they encounter distinct challenges. Similar to previous articles, the health and wellbeing of the Syrian and Lebanese people are hindered by the inequities and inequalities stemming primarily from warfare. Impact of war on healthcare: Syria's deliberate destruction Since the onset of the Syrian conflict in 2011, the country’s healthcare system has been systematically dismantled. Beyond the direct casualties of war, the destruction of hospitals, clinics, and medical supply chains has led to a secondary crisis, one where preventable deaths become inevitable. Between 2011 and 2020, Physicians for Human Rights documented nearly 600 attacks on healthcare facilities. The deliberate targeting of hospitals and medical personnel has rendered healthcare not just a casualty of war, but a weapon of war itself ( Figure 1 ). This destruction has had catastrophic consequences. Maternal and infant mortality rates have soared, vaccination coverage has plummeted, and chronic disease management has become nearly impossible. In the northwest of Syria, where displaced populations reside in makeshift camps, infectious diseases such as cholera and tuberculosis continue to spread due to poor sanitation and lack of medical oversight. The COVID-19 pandemic only exacerbated these challenges, whereby 46% of reported cases in Northwest Syria resulted in death due to the collapse of medical infrastructure. As of early 2025, only 57% of hospitals and 37% of primary healthcare centres in Syria remain fully functional. The remaining facilities operate under severe constraints due to damage from attacks and resource shortages. In 2024 alone, there were 77 attacks on healthcare facilities, further disrupting access to trauma care, maternal health, and treatment for chronic illnesses. Overcrowding in displacement camps and poor sanitation have also heightened the risk of outbreaks such as tuberculosis, making urgent intervention critical ( Figure 2 ). Impact of war on healthcare: Lebanon's fragile healthcare system Lebanon, a country once regarded as a regional medical hub, has borne the brunt of Syria’s refugee crisis. With an estimated 1.5 million Syrian refugees seeking shelter within its borders, the country has faced a 50% surge in demand for healthcare services. The healthcare system, already strained before the crisis, has since crumbled under the weight of economic collapse, political instability, and donor fatigue. The Lebanese economic crisis, which began in 2019, had devastating effects on healthcare delivery. The Lebanese pound has lost over 90% of its value, placing essential medical supplies out of reach for hospitals and individuals. Pharmacies frequently run out of life-saving medications, power outages disrupt critical care units, and the departure of healthcare professionals has left hospitals understaffed. The situation has worsened due to escalating hostilities, starting from the south of Lebanon and later expanding, displacing over 112,000 people as of February 2025. The violence has led to the closure of 130 primary health centres and seven hospitals, with 15 out of 153 hospitals either non-functional or operating at reduced capacity. In Nabatieh Governorate alone, 40% of hospital bed capacity has been lost. Attacks on health workers and facilities continued to mount between January and November 2024, when 137 attacks were reported, nearly half of which resulted in fatalities. These disruptions create a ripple effect, limiting immediate medical care and undermining public health initiatives such as vaccination programs and maternal health services. NGOs: the last line of defence In the face of government inaction, non-governmental organisations (NGOs) have become the backbone of healthcare provision in Syria and Lebanon. International and local NGOs have mobilised to provide vaccination campaigns, mental health support, and medical supplies to those in need. For example, WHO and UNICEF have facilitated vaccination drives, reaching 250,000 children under five years old, 30% of whom were displaced Syrians. However, while NGOs have played a crucial role in mitigating healthcare crises, their efforts remain primarily reactive rather than systemic and preventative, addressing immediate needs without long-term sustainability, and not adequately focusing on precautionary measures to avoid these undesirable situations. In fact, NGOs face mounting challenges. The overwhelming demand for services, lack of sustainable funding, and security threats have made it increasingly difficult for organisations to operate. Moreover, while NGOs are stretched in their deliverables, the humanitarian workers encounter frequent targeting, making their mission even more perilous. Conclusion: the role of the international community The crises in Syria and Lebanon are not isolated events; they are a reflection of global health injustices that demand international attention and intervention. Providing short-term aid is no longer enough, so long-term solutions must be prioritised to rebuild these destroyed healthcare systems. Moreover, de-escalating both crises would improve health outcomes for the vulnerable communities in Syria and Lebanon. The next article will focus on the population in conflicted Kashmir; addressing their injustices is crucial because of the profound impact and lack of coverage in mainstream discussions. Written by Jana Antar and Sam Jarada Related articles: Understanding health through different stances / Socioeconomic health equalities REFERENCES A Decade of Destruction: Attacks on health care in Syria. The IRC. 2025. Available from: https://www.rescue.org/report/decade-destruction-attacks-health-care-syria-0 The Syrian Conflict: Eight Years of Devastation and Destruction of the Health System - PHR. PHR. 202. Available from: https://phr.org/our-work/resources/the-syrian-conflict-eight-years-of-devastation-and-destruction-of-the-health-system/ Ammar W, Kdouh O, Hammoud R, Hamadeh R, Harb H, Ammar Z, et al. Health system resilience: Lebanon and the Syrian refugee crisis. Journal of Global Health. 2016 Dec;6(2). Available from: https://pmc.ncbi.nlm.nih.gov/articles/PMC5234495/ Lebanon 2025 Indicators and Targets Lebanon Multi-year Strategy 2023 -2025. Available from: https://reporting.unhcr.org/sites/default/files/2025-01/Lebanon%20-%20Strategy%202023%20%E2%80%93%202025_0.pdf Lebanon | Humanitarian Action. Humanitarianaction.info . 2024. Available from: https://humanitarianaction.info/document/global-humanitarian-overview-2025/article/lebanon-1 WHO. WHO’s Health Emergency Appeal 2025 [Internet]. 2025. Available from: https://cdn.who.int/media/docs/default-source/documents/emergencies/2025-appeals/2025-hea-lebanon.pdf?sfvrsn=45f2a018_5&download=true Lebanon’s Pharmaceutical Sector: Challenges, Opportunities, and Strategic Solutions. LCPS. 2025. Available from: https://www.lcps lebanon.org/en/articles/details/4903/lebanon%E2%80%99s-pharmaceutical-sector-challenges-opportunities-and-strategic-solutions Sousa C, Akesson B, Badawi D. “Most importantly, I hope God keeps illness away from us”: The context and challenges surrounding access to health care for Syrian refugees in Lebanon. Global Public Health. 2020 Jun 12;1–10. Syrian refugee access to healthcare in Lebanon - Lebanon. ReliefWeb. 2020. Available from: https://reliefweb.int/report/lebanon/syrian-refugee-access-healthcare-lebanon World. Lebanon: a conflict particularly destructive to health care [Internet]. Who.int . World Health Organization: WHO; 2024. Available from: https://www.who.int/news/item/22-11-2024-lebanon--a-conflict-particularly-destructive-to-health-care Project Gallery